Commercial software for data acquisition and event analysis for neuroscience research and education is often expensive and sometimes not user friendly for faculty and students. We present “g-PRIME”, a Windows based data acquisition, event/spike capturin...

Transient rhabdom shedding (TRS), the invertebrate analog of rod outer segment disc shedding, is primed by >3-5 h of overnight circadian efferent outflow and triggered by dawn in the horseshoe crab Limulus (J. Neurosci. 4:2792). Efferent input to the lateral eye is octopaminergic and activates adenylate cyclase through a G-protein coupled receptor leading to a rise in [cAMP]i and activation of cAMP-dependent protein kinase (PKA). The long-term activation of PKA required to prime the retina for TRS suggests that efferent input may regulate photoreceptor gene expression. We investigated whether protein synthesis is required for octopaminergic priming for TRS. Microinjection (1.4 μl/min) of 40 μM octopamine (OA) into lateral eyes (n=7) for 6 h in darkness during subjective day (no efferent input) primed 47.5% of 70 photoreceptors examined for TRS. TRS was triggered by a 20-min pulse of broad-spectrum artificial lighting (2400 cd/m2). Co-injection of 1 mM cycloheximide (CHX; protein synthesis inhibitor) and...

The Society for Neuroscience (SfN) has selected 10 members from a highly competitive applicant pool to participate in the Society’s annual Capitol Hill Day on March 6–8, 2023.

Read advocacy news from the week of October 28, 2016.

Neuroadaptations within the glutamatergic pathway projecting from the pre-frontal cortex (PFC) to the nucleus accumbens (NAc) that occur during withdrawal from cocaine self-administration are critical for cocaine prime-induced reinstatement of cocaine-s...

The transition from drug use to abuse involves escalation of drug intake over time. In animal models, rats that have prolonged access to intravenous cocaine increase their intake over repeated sessions whereas rats with limited access retain stable responding over time. Recently, the mGlu2/3 agonist, LY379268, has been found effective in blocking cue-induced reinstatement of cocaine-seeking behavior. However, LY379268 had little effect attenuating cocaine-self-administration. These experiments, however, were conducted in rats given only limited access to cocaine (2 hours) and it is possible that LY379268 is more effective in reducing cocaine self-administration and cocaine prime-induced reinstatement in rats following extended access to cocaine. It was of interest, therefore, to investigate the effects of LY379268 on cocaine self-administration and cocaine prime-induced reinstatement in rats with a history of long cocaine access vs. short access. Male Wistar rats were trained to self-administer cocaine (0....

Week of March 18, 2019: Read the Latest Advocacy and Science News

SfN enthusiastically announces that Neuroscience 2021 will be held in an inclusive hybrid format. Neuroscience 2021 is one annual meeting with two experiences: for the first time, a four-day full virtual program (November 8-11, 2021) including reimagined virtual posters, and a four-day full in-person program in Chicago at McCormick Place Convention Center (November 13–16, 2021).

The Society for Neuroscience (SfN) has selected 15 members from a highly competitive applicant pool to participate in the Society’s annual Capitol Hill Day on March 22–24, 2022.

The present study was conducted to elucidate the role of the kappa opioid receptor in mediating stress- and drug-induced reinstatement of a cocaine conditioned place preference (CPP). C57BL/6, kappa receptor knockout (KO) and wildtype (wt) and preprodyn...