We experience our visual environment in discrete glances. How do we build a unified representation of a 360º visual environment? One possibility is that neighboring scene views become associated through concurrent activation during learning, enabling a ...

Cholinergic stimulation from the septum induces theta oscillations in the hippocampus. In this study, we use patch clamp recording from acute mouse slices to investigate muscarine-induced changes in intrinsic membrane conductances in CA1 oriens/alveus (OA) interneurons. The M-current (IM) is a voltage-gated potassium conductance that plays a key role in control of cell excitability. In 11 of 17 cells, bath application of 10μM muscarine caused a 72.5±6.8% inhibition of IM (p<0.0001) and an increase in action potential (AP) firing of 7.2±2.2 Hz (p=0.008). The same cells also showed a loss of accommodation that was not completely explained by inhibition of IM. The slow afterhyperpolarization (sIAHP) is a Ca2+-dependent potassium conductance. Muscarine inhibited the sIAHP by 74.1±6.0% (p=0.001, n=9), which unmasked a Ca2+/Na+ dependent inward afterdepolarization (IADP) that could be demonstrated in the absence of muscarine by addition of 10mM TEA. The timing of the shift in the balance between the sIAHP and IA...

Ibudilast is a non-selective phosphodiesterase (PDE) inhibitor and glia cell modulator which has been used clinically to treat asthma and other inflammatory diseases. It has shown great promise for the treatment of drug and alcohol use disorders in rece...

The Society for Neuroscience (SfN) has selected 10 members from a highly competitive applicant pool to participate in the Society’s annual Capitol Hill Day on March 12–14, 2024.

The Society for Neuroscience (SfN) has selected 10 members from a highly competitive applicant pool to participate in the Society’s annual Capitol Hill Day on March 12–14, 2024.

Accumulation of aggregated amyloid β-protein (Aβ) in the brain is thought to be the initiating event, leading to neurodegenetation and dementia in Alzheimer’s disease (AD). Therefore, therapeutic strategies that clear accumulated Aβ and/or prevent Aβ pr...

Introduction Evidence exists that both right and left hemisphere attentional mechanisms are mobilized when attention is directed to the right visual hemifield and only right hemisphere attentional mechanisms are mobilized when attention is directed to t...

SfN offers an array of sponsored products and advertising opportunities to extend your reach and tailor to your brand, budget, audience, and marketing goals.

SfN offers an array of sponsored products and advertising opportunities to extend your reach and tailor to your brand, budget, audience, and marketing goals.

Detection of angular and translational body motion derives from sensory transformations within otolith and semicircular canal organs. Signals are transmitted to the brain by the VIIIth nerve with an anterior branch that carries afferents from the saccul...