The Society for Neuroscience (SfN) has selected 10 members from a highly competitive applicant pool to participate in the Society’s annual Capitol Hill Day on March 12–14, 2024.

Thank you for attending Neuroscience 2019!

Read science policy and advocacy news from the week of April 13, 2018

Marker-based motion capture (MBMC) is a powerful tool for precise, high-speed, three-dimensional tracking of animal movements, enabling detailed study of behaviors ranging from subtle limb trajectories to broad spatial exploration. Despite its proven utility in larger animals, MBMC has remained underutilized in mice due to the difficulty of robust marker attachment during unrestricted behavior. In response to this challenge, markerless tracking methods, facilitated by machine learning, have become the standard in small animal studies due to their simpler experimental setup. However, trajectories obtained with markerless approaches at best approximate ground-truth kinematics, with accuracy strongly dependent on video resolution, training dataset quality, and computational resources for data processing. Here, we overcome the primary limitation of MBMC in mice by implanting minimally invasive markers that remain securely attached over weeks of recordings. This technique produces high-resolution, artifact-free...

Retinal ganglion cells (RGCs), the projection neurons of the eye, cannot regenerate their axons once the optic nerve is injured and soon begin to die, precluding visual recovery after traumatic or ischemic nerve damage or in degenerative diseases such a...

This study addresses the question of how posture and movement are oriented with respect to the direction of gravity. It is suggested that neural control levels coordinate spatial thresholds at which multiple muscles begin to be activated in order to spe...

The mouse cortex contains a multitude of cell types segregated into layers and functionally distinct regions. To begin to understand the diversity of cell types across the mouse cortex, we have analyzed >11,000 neurons from the primary visual cortex (VI...

Increasing data suggest a crucial relationship between glycolipid metabolic disorder and neuropsychiatric injury. The aim of this study is to investigate the behavioral performance changes and neuropathological injuries in mice challenged with high-fat diet (HFD) and streptozotocin (STZ). The glucose metabolism indicators and behavioral performance were detected. The mRNA expression of IL-1β, IL-6, TNF-α, ocln, zo-1, and clnds and protein expression of APP, p-Tau, p-IRS1, p-AKT, p-ERK, and TREM1/2 were measured. The fluorescence intensities of MAP-2, NeuN, APP, p-Tau, GFAP, and IBA-1 were observed. The results showed that combination of HFD and STZ/I.P. could induce glucose metabolic turmoil and Alzheimer's disease (AD)-like neuropsychiatric dysfunction in mice, as indicated by the increased concentrations of fasting blood glucose and impaired learning and memory ability. Moreover, the model mice presented increased levels of APP, p-Tau, p-IRS1, TREM2, IL-1β, IL-6, TNF-α, ocln, zo-1, and clnds; decreased l...

Contribute to advancing science education and advocate for public policies that support neuroscience research.

Contribute to advancing science education and advocate for public policies that support neuroscience research.