Learn strategies for neuroscience advocacy – including communicating with the public, connecting with legislators, and organizing on a local level – with these new resources available on Neuronline.

LSD alters the activity of brain regions involved in differentiating between oneself and another person.

Read Marina Picciotto's first editorial about her plans as JNeurosci's new editor-in-chief »

Read science policy and advocacy news from the week of March 16, 2018

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Retinal ganglion cells (RGCs), the projection neurons of the eye, cannot regenerate their axons once the optic nerve is injured and soon begin to die, precluding visual recovery after traumatic or ischemic nerve damage or in degenerative diseases such a...

This study addresses the question of how posture and movement are oriented with respect to the direction of gravity. It is suggested that neural control levels coordinate spatial thresholds at which multiple muscles begin to be activated in order to spe...

The mouse cortex contains a multitude of cell types segregated into layers and functionally distinct regions. To begin to understand the diversity of cell types across the mouse cortex, we have analyzed >11,000 neurons from the primary visual cortex (VI...

Reduced ability to maintain body temperature in colder environments may contribute to the development of obesity in adulthood.

Fragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1 family, has been linked to psychiatric disorders including autism and schizophrenia. Parvalbumin (PV) interneurons play critical roles in cortical processing and have been implicated in FXR1-linked mental illnesses. Targeted deletion of FXR1 from PV interneurons in mice has been shown to alter cortical excitability and elicit schizophrenia-like behavior. This indicates that FXR1 regulates behaviorally relevant electrophysiological functions in PV interneurons. We therefore expressed a genetically encoded hybrid voltage sensor in PV interneurons and used voltage imaging in slices of mouse somatosensory cortex to assess the impact of targeted FXR1 deletion. These experiments showed that PV interneurons lacking FXR1 had excitatory synaptic potentials with larger amplitudes and shorter latencies compared with wild type. Synaptic potential rise-times, decay-times, and half-widths were also impacted to degrees that varied bet...