Neuroscience 2005 Abstract
| Presentation Number: | 595.10 |
|---|---|
| Abstract Title: | Enhanced neurogenesis following long-term potentiation induction in the rat fascia dentata. |
| Authors: |
Chun, S.*1
; Jung, M.1
1Neuroscience Laboratory, Inst. for Med. Sciences, Ajou Univ. School of Medicine, Suwon, Democratic People's Republic of Korea |
| Primary Theme and Topics |
Development - Neurogenesis and Gliogenesis -- Proliferation |
| Session: |
595. Adult Neurogenesis Regulated by Brain Activity and Cellular Environment Poster |
| Presentation Time: | Tuesday, November 15, 2005 9:00 AM-10:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # B8 |
| Keywords: | BrdU, Neurogenesis, Dentate gyrus, Long-term potentiation |
The dentate gyrus (DG) is among the few areas in the mammalian brain where production of new neurons continues in the adulthood. Although its functional significance is not completely understood, several lines of evidence suggest the role of DG neurogenesis in learning and memory. Considering that long-term potentiation (LTP) is a prime candidate for the process underlying hippocampal learning and memory, these studies raise the possibility that LTP and neurogenesis are linked together. Indeed, a previous study (Brain Res, 857:300-307, 2000) has shown that LTP induction in Mossy fiber projection to CA3, i.e., the efferent pathway of the DG, enhanced proliferation of progenitor cells in the DG. However, it is unknown whether LTP in the afferent pathway is associated with neurogenesis. We investigated this matter by inducing LTP in perforant path-DG synapses by theta burst stimulation in one hemisphere, and comparing newly generated progenitor (BrdU-positive) cells in the DG between two hemispheres. Compared with the control hemisphere (stimulated with low-frequency pulses), the LTP-induced hemisphere contained a significantly higher number of newly generated progenitor cells in the dorsal as well as ventral DG. When CPP, an NMDA receptor antagonist, was treated, no difference was detected between two hemispheres, indicating that NMDA receptor activation, rather than burst stimulation per se, is responsible for enhanced proliferation. The present results suggest that LTP and neurogenesis share the same cellular processes up to NMDA receptor activation, and supports the possibility that neurogenesis plays a role in learning and memory.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
Copyright © 2005-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
