Neuroscience 2001 Abstract
| Presentation Number: | 633.1 |
|---|---|
| Abstract Title: | Calcium binding proteins, NK1 receptors, and compartments in the ventral respiratory group of the rat. |
| Authors: |
Alheid, G. F.*1,2
; Gray, P. A.3
; Habtemarkos, R.1
; Feldman, J. L.3
; McCrimmon, D. R.1,2
1Dept of Physiology, Northwestern University Medical School, Chicago, IL 2Institute for Neuroscience, Northwestern University Medical School, Chicago, IL 3Dept of Neurobiology, UCLA School of Medicine, Los Angeles, CA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Respiratory regulation |
| Secondary Theme and Topics | Motor Systems<br />- Pattern Generation |
| Session: |
633. Autonomic: respiratory regulation--rhythm generation Poster |
| Presentation Time: | Tuesday, November 13, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall QQ-2 |
| Keywords: | RESPIRATION, PARVALBUMIN, CALRETININ, CALBINDIN |
The calcium binding proteins, parvalbumin, calretinin, and calbindin are found in the ventral respiratory group (VRG) of the medulla. We have shown earlier that parvalbumin cells may be retrogradely labeled from the VRG or from the phrenic nucleus (Alheid et al,SFN 2000). Here we compare the immunohistochemistry of these three proteins with that for the substance P (NK1) receptor which is found in cell bodies of the preBotzinger complex (preBotC), but not in the other compartments of the VRG (Gray et al, Science, 286,1566, 1999). Parvalbumin neurons are labeled extensively within the VRG, particularly in rostral VRG and in the Botzinger complex (BotC). Parvalbumin positive cells are scarce in the pBC and are never co-localized with NK1. Caudal to the BotC is an area that appears to be poor for both parvalbumin and NK1 cells. Calbindin neurons are scattered in the region of the VRG but are scarce or absent from the BotC. Calbindin neurons intermingle, but do not co-localize with NK1 cells in preBotC. Calretinin neurons appear within the general area of the VRG, but are rare within BotC. Double labeling with NK1 is seen in a sub-group of calretinin neurons, found at the rostral end of the rostral VRG and caudal to the main mass of NK1 positive neurons in the preBotC. These data demonstrate that the expression of calcium binding proteins may help to anatomically identify established or novel functional compartments in the respiratory columns of the medulla.
Supported by NIH grants HL40959, HL60097,HL60969, and an APS Porter Development Award (PAG)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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