Neuroscience 2005 Abstract
| Presentation Number: | 573 |
|---|---|
| Abstract Title: | Neurobiological mechanisms of the placebo effect. |
| Authors: |
Zubieta, J.*1
; Benedetti, F.2
; Mayberg, H. S.3
; Wager, T. D.4
; Stohler, C. S.
1Psychiatry, Univ. of Michigan, Ann Arbor, MI 2Radiology, Univ. of Michigan, Ann Arbor, MI 3Italy, Mental Hlth Res Inst 05 Zina Pitcher Pl, 48109-0720, 4Neuroscience, Mental Hlth Res Inst 05 Zina Pitcher Pl, 48109-0720, |
| Primary Theme and Topics |
Cognition and Behavior - Motivation and Emotion -- Reward |
| Secondary Theme and Topics | Sensory and Motor Systems<br />- Pain<br />-- Pain imaging and perception |
| Session: |
573. Symposium: Neurobiological Mechanisms of the Placebo Effect Symposium |
| Presentation Time: | Tuesday, November 15, 2005 8:30 AM-11:00 AM |
| Location: | Washington Convention Center - Ballroom B |
| Keywords: | placebo effect, mood, pain, motor function |
The placebo effect is a phenomenon of importance in the clinical practice of medicine, and a prime example of cognitive-emotional influences on a number of physical processes.
Dr. Benedetti will present work studying the placebo response in Parkinson patients at the single neuron level. Placebo administration induced a decrease of firing rate as well as the disappearance of bursting activity of subthalamic nucleus neurons. These neuronal changes were correlated with clinical assessments of decreased muscle rigidity. These data show that complex mental activities, like expectancies and beliefs, are capable of changing neuronal functioning which, in turn, induce clinical improvement.
Dr. Mayberg will present data on the neural responses to placebo in clinical trials of antidepressants. In this study, placebo response was associated with a complex set of limbic and cortical metabolic changes that overlapped with those seen in responders treated with active fluoxetine.
Dr. Wager will then present work on the neural circuits implicated in the placebo effect. In this talk, recent findings on placebo analgesic effects in pain models and other domains will be reviewed. Pain models, used most frequently for the demonstration of the placebo effect, will be described in detail as to their neural representations.
Dr. Stohler will follow by presenting studies which examine directly the neurochemical mechanisms that underlie placebo effects during expectation of analgesia. Data will be presented on the changes in the activity of this neurotransmitter system during pain in the presence and absence of a placebo. This information will be integrated with that presented by previous speakers to examine the overlap, and differences, in the regional effects of placebo interventions for the various experimental and clinical conditions covered in the symposium.
8:30 573.1 Introductory Remarks. J. ZUBIETA, Univ. of Michigan
8:35 573.2 Biological Effects of Placebos: from pharmacology to single neuron recording. F. BENEDETTI, Univ. of Turin
9:05 573.3 Neural Responses to Placebo in Clinical Trials of Antidepressants. H.S. MAYBERG, Emory Univ.
9:35 573.4 Neural Circuits Implicated in the Placebo effect. T.D. WAGER, Columbia Univ.
10:05 573.5 Neurochemical Responses to Placebo. C.S. STOHLER, Dental School, Univ. of Maryland.
Dr. Benedetti will present work studying the placebo response in Parkinson patients at the single neuron level. Placebo administration induced a decrease of firing rate as well as the disappearance of bursting activity of subthalamic nucleus neurons. These neuronal changes were correlated with clinical assessments of decreased muscle rigidity. These data show that complex mental activities, like expectancies and beliefs, are capable of changing neuronal functioning which, in turn, induce clinical improvement.
Dr. Mayberg will present data on the neural responses to placebo in clinical trials of antidepressants. In this study, placebo response was associated with a complex set of limbic and cortical metabolic changes that overlapped with those seen in responders treated with active fluoxetine.
Dr. Wager will then present work on the neural circuits implicated in the placebo effect. In this talk, recent findings on placebo analgesic effects in pain models and other domains will be reviewed. Pain models, used most frequently for the demonstration of the placebo effect, will be described in detail as to their neural representations.
Dr. Stohler will follow by presenting studies which examine directly the neurochemical mechanisms that underlie placebo effects during expectation of analgesia. Data will be presented on the changes in the activity of this neurotransmitter system during pain in the presence and absence of a placebo. This information will be integrated with that presented by previous speakers to examine the overlap, and differences, in the regional effects of placebo interventions for the various experimental and clinical conditions covered in the symposium.
8:30 573.1 Introductory Remarks. J. ZUBIETA, Univ. of Michigan
8:35 573.2 Biological Effects of Placebos: from pharmacology to single neuron recording. F. BENEDETTI, Univ. of Turin
9:05 573.3 Neural Responses to Placebo in Clinical Trials of Antidepressants. H.S. MAYBERG, Emory Univ.
9:35 573.4 Neural Circuits Implicated in the Placebo effect. T.D. WAGER, Columbia Univ.
10:05 573.5 Neurochemical Responses to Placebo. C.S. STOHLER, Dental School, Univ. of Maryland.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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