Neuroscience 2001 Abstract
| Presentation Number: | 576.6 |
|---|---|
| Abstract Title: | 1.5T fMRI reliably detects neuronal response to brief noxious mechanical stimuli in single subjects. |
| Authors: |
Aquino, P.*1
; Kong, J.1
; Dershwitz, M.3
; Gracely, R. H.2
; Kramer, T.1
; Gollub, R.1
1Psychiatry, MGH, Charlestown, MA 2NIDCR, Bethesda, MD 3UMass MC, Worcester, MA |
| Primary Theme and Topics |
Sensory Systems - Pain -- Functional imaging, psychophysics, human behavior |
| Session: |
576. Pain: imaging Slide |
| Presentation Time: | Tuesday, November 13, 2001 2:15 PM-2:30 PM |
| Location: | Room 33C |
| Keywords: |
Experimental paradigms that provide reliable and quantitative measures of the neuronal correlates of subjective perception of pain are necessary prerequisites to the clinical utility of functional neuroimaging to study pain related disorders. The study was approved by the IRB at MGH. Subjects (5 M, 4 F, 28±3 yrs) received minimal noxious mechanical pressure stimuli to one shin consisting of 6 pairs of stimuli 2 seconds in duration 3 seconds apart per 4 minute scan. Pressure stimulus intensity was individualized to elicit sensory and affective ratings in the mild and moderate ranges. Thermal stimuli eliciting the same subjective ratings were used for comparison. Subjects rated stimulus intensity after each of these 8 scans (right/left shin X mild/moderate intensity X mechanical/thermal stimuli).
Whole brain EPI was performed on a 1.5T Siemens MRI system. Despite comparable ratings, thermal heat pain was less effective than mechanical pressure pain at eliciting cortical activation. Mechanical stimuli produced robust fMRI signal increases in 9/9 subjects in the STG, in 8/9 in right M1 and SMG, in 7/9 in ACC, S2, SMA, and LPMC. In 6/9 subjects we observed significant activation in left S1, M1 and STG, and bilateral SPL. And 5/9 subjects had activation in right S1. Average S1 activation was 1.7% (range 1.0-4.0%) in the left hemisphere and 1.0% (0.5-1.4%) on the right. More than half the subjects had several discrete clusters bilaterally in S1, S2, M1, and right SMG. Both stimulus modalities were effective in producing caudate, medial thalamic and cerebellar (lobule VI) activation in group averaged data.
Whole brain EPI was performed on a 1.5T Siemens MRI system. Despite comparable ratings, thermal heat pain was less effective than mechanical pressure pain at eliciting cortical activation. Mechanical stimuli produced robust fMRI signal increases in 9/9 subjects in the STG, in 8/9 in right M1 and SMG, in 7/9 in ACC, S2, SMA, and LPMC. In 6/9 subjects we observed significant activation in left S1, M1 and STG, and bilateral SPL. And 5/9 subjects had activation in right S1. Average S1 activation was 1.7% (range 1.0-4.0%) in the left hemisphere and 1.0% (0.5-1.4%) on the right. More than half the subjects had several discrete clusters bilaterally in S1, S2, M1, and right SMG. Both stimulus modalities were effective in producing caudate, medial thalamic and cerebellar (lobule VI) activation in group averaged data.
Supported by NIDA, Dana Foundation
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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