Neuroscience 2002 Abstract
| Presentation Number: | 574.21 |
|---|---|
| Abstract Title: | Validation of Rat Models for Hot Flush. |
| Authors: |
Leventhal, L.*1
; O'Connor, L.1
; Sipe, K.1
; Funkhouser, J.1
; Johnston, G.1
; Deecher, D. C.1
; Merchenthaler, I.1
1Wyeth Pharmaceuticals, Women's Health Res Inst, Collegeville, PA |
| Primary Theme and Topics | Neurological and Psychiatric Conditions |
| Secondary Theme and Topics | Cognition and Behavior |
| Session: |
574. Neuroendocrine: steroid/brain interactions V Poster |
| Presentation Time: | Tuesday, November 5, 2002 1:00 PM-2:00 PM |
| Location: | Hall A2-B3 M-9 |
| Keywords: | estrogen, menopause, hot flash, thermoregulation |
Hot flushes are generally a consequence of declining sex steroid hormone levels and a prime reason why menopausal women seek medical treatment. A hot flush generally lasts several minutes and consists of a warming sensation in the chest and face accompanied by sweating, vasodilation (flushing) and in some instances, feelings of nausea and illness. Currently, estrogens and/or some progestins are the most effective therapeutics for the treatment of hot flushes. Although steroid hormone treatments are a very effective means of alleviating hot flushes, these therapies are not acceptable or indicated for all women. Thus, non-steroid hormonal therapies (e.g. venlafaxine, fluoxetine, paroxetine, clonidine, gabapentin) are being evaluated clinically even though they are less effective than sex steroids. We have modified and developed rat models for vasomotor instability based on measuring tail skin temperature (TST) in ovariectomized (OVX) rats. The first model includes modification and optimization of the classical morphine-dependent OVX rat model. The second model is based on OVX-induced TST elevation. Tail skin temperatures can be measured by two methods: with a thermistor (short-term) or with a subcutaneously implanted telemetric device (long-term). These rat models of vasomotor instability have been validated with known therapeutics (i.e., estrogen and clonidine). These models can be utilized to study the physiology and the neuronal circuitry(s) involved in thermoregulatory dysfunction. The advantages and disadvantages of each model will be discussed.
Research supported by Wyeth Research.
Research supported by Wyeth Research.
Supported by Wyeth Research
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
Copyright © 2002-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
