Neuroscience 2005 Abstract
| Presentation Number: | 474.9 |
|---|---|
| Abstract Title: | A multi-site fMRI study of the novelty oddball task in schizophrenia: effects of illness duration. |
| Authors: |
Clark, V. P.*1,2
; Friedman, L.1,2
; Manoach, D. S.1
; Ho, B. C.1
; Lim, K. O.1,3
; Andreasen, N. C.1,2
1The MIND Inst., Albuquerque, NM 2NM, 801 University Boulevard, 87106, 3USA, 801 University Boulevard, 87106, |
| Primary Theme and Topics |
Disorders of the Nervous System - Cognitive, Emotional and Behavioral State Disorders -- Schizophrenia: Functional deficits |
| Secondary Theme and Topics | Techniques in Neuroscience<br />- Data Analysis and Statistics |
| Session: |
474. Schizophrenia: Functional Deficits II Slide |
| Presentation Time: | Monday, November 14, 2005 3:00 PM-3:15 PM |
| Location: | Washington Convention Center - Room 154A |
| Keywords: | ANTIPSYCHOTIC, BRAIN IMAGING, AUDITORY, NEURODEGENERATION |
While the reduced auditory P3 event-related potential (ERP) evoked by the auditory oddball task is a highly sensitive marker for schizophrenia, it is relatively non-specific, and its neural basis is uncertain. In addition, most previous studies have examined few first-episode patients (FEP), reducing statistical power for the detection of changes in neural activity with progression of this illness. In order to increase the specificity and sensitivity of this measure for illness progression, functional magnetic resonance imaging (fMRI) data, which offers improved anatomic specificity over ERPs, was obtained using the novelty oddball task at 4 institutions and combined for analysis. FMRI data was first obtained from 10 healthy subjects in 2 sessions at each of 4 MIND Consortium sites, using 3 Tesla (Siemens Trios at UMN, U Iowa and MGH) and 1.5 Tesla systems (GE at U Iowa and Siemens at UNM). Whole-brain, gradient-echo, echo planar imaging data (TR= 2 sec) was acquired in response to standard (10% of stimuli, 1000 Hz), novel (10%, computer generated tones) and target stimuli (10%, 1200 Hz, manual response) presented for 200 msec, (ISI range 550 to 2050 msec). Data were analyzed using fMRIstat and SAS. To date, fMRI data has been obtained from over 55 non-FEP and 20 FEP, with 70 healthy volunteers as collection continues. Generally good replication was found across sites when data were smoothed to an equal amount. Comparisons between healthy and schizophrenic subjects revealed a reduction in BOLD response amplitude across brain regions. FEP showed larger responses than non-FEP in temporal, somato-motor and PFC regions. By providing larger sample sizes for more sensitive detection of differences in brain function, this multi-site study found that responses in FEP and non-FEP were consistent with widespread deficits in neural networks, with progression of deficits over time.
Supported by DOE Grant DE-FG02-99ER62764
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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