Neuroscience 2003 Abstract
| Presentation Number: | 422.12 |
|---|---|
| Abstract Title: | Intra-accumbal shell administration of the D1-like dopamine receptor agonist, SKF-81297, reinstates drug seeking behavior. |
| Authors: |
Schmidt, H. D.*1
; Pierce, C.1
1Pharmacol., Boston Univ. Sch. of Med., Boston, MA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Cocaine |
| Session: |
422. Addiction and Drugs of Abuse: Cocaine V Poster |
| Presentation Time: | Monday, November 10, 2003 11:00 AM-12:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # UU16 |
| Keywords: | Reinstatement, Cocaine, Nucleus Accumbens |
While increasing evidence demonstrates a role for enhanced dopamine transmission in cocaine priming-induced reinstatement of drug seeking, the circuitry mediating drug seeking has not been fully described. The goal of these experiments is to further elucidate the role of mesoaccumbal dopaminergic pathways in the reinstatement of cocaine-seeking behavior. Initially, rats were trained to press a lever for cocaine (0.254 mg/60 ?l, i.v.) using a fixed-ratio five (FR5) schedule of reinforcement. Responding then was extinguished by substituting saline for cocaine. Following extinction, the ability of a systemically administered dopamine transporter blocker, GBR 12909, to induce reinstatement of cocaine seeking was assessed. A priming injection of GBR 12909 (10 mg/kg, i.p.) reinstated drug-seeking behavior to levels of responding that were not statistically different from those produced by a cocaine prime (10 mg/kg, i.p.), which confirms that increased dopaminergic transmission plays a critical role in priming-induced reinstatement of cocaine seeking. In order to determine which dopamine receptor subtypes in the nucleus accumbens are responsible for promoting the reinstatement of cocaine seeking, we microinjected a D1-like dopamine receptor agonist directly into the core and shell of the nucleus accumbens. Administration of the D1-like dopamine receptor agonist, SKF-81297 (1.0 µg/0.5 µl), into the nucleus accumbens shell, but not core, reinstated drug-seeking behavior. These results indicate that activation of D1-like receptors in the nucleus accumbens shell promotes cocaine seeking, which contrasts previous research showing that the systemic injection of a D1-like dopamine receptor agonist blocks reinstatement of cocaine seeking.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
Copyright © 2003-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
