Neuroscience 2002 Abstract
| Presentation Number: | 460.10 |
|---|---|
| Abstract Title: | SINGLE-AXON TRACING OF THE CENTRE MEDIAN EFFERENT PROJECTIONS IN PRIMATES. |
| Authors: |
Parent, M.*1
; Levesque, M.1
; Parent, A.1
1Centre de Recherche Universite Laval Robert-Giffard, Beauport, Canada |
| Primary Theme and Topics |
Motor Systems - Basal Ganglia -- Anatomy |
| Session: |
460. Basal ganglia: anatomy--efferents and afferents Poster |
| Presentation Time: | Tuesday, November 5, 2002 9:00 AM-10:00 AM |
| Location: | Hall A2-B3 I-9 |
| Keywords: | CENTRE MEDIAN, THALAMOSTRIATAL PROJECTIONS, THALAMOCORTICAL PROJECTIONS, INTRALAMINAR THALAMIC NUCLEI |
In this study of the efferent projections of the centre median thalamic nucleus (CM) in squirrel monkeys (Saimiri sciureus), microiontophoretic injections of BDA combined with electrophysiological recording led to the Golgi-like labeling of 7 large CM perikarya from which emerged several long, poorly branched and sparsely spined dendrites. Entire reconstruction of the axon of these neurons revealed a similar pattern of distribution. Each axon coursed through the lateral thalamic nuclei, emitted a few collaterals in the reticular thalamic nucleus, and bifurcated within the internal capsule. One branch ascended via the corona radiata to the motor cortex, where it arborized moderately in layers V and VI, and much less profusely in layer I. The other branch ran through the pallidum and entered the dorsolateral sector of the putamen (sensorimotor territory), where it broke out into 3-5 smaller collaterals. These thin branches divided into numerous shorter collaterals that displayed pedunculated varicosities organized as dense, cluster-like terminal fields that formed oblique bands restricted to specific domains or the dorsolateral putamen. In contrast to previous results obtained with double-retrograde labeling techniques, our data revealed that the motor cortex and the sensorimotor striatal territory are innervated by the same CM axons in primates and that the CM axonal arborization is much more profuse in the striatum than in the cortex. The CM axons analyzed here did not innervated extrastriatal basal ganglia components, a finding that suggests a major difference between rodents and primates in regard to the organization of the thalamostriatal projection.
Supported by CIHR, NSERC, FRSQ
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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