Neuroscience 2001 Abstract
| Presentation Number: | 430.18 |
|---|---|
| Abstract Title: | EFFECTS OF SEX AND HORMONAL STATUS ON ASTROCYTIC FGF-2-IR AFTER LESIONS OF THE NIGROSTRIATAL DOPAMINE NEURONS. |
| Authors: |
Moroz, I. A.*1
; Stewart, J.1
1Dept Psychol, Concordia Univ, Montreal, Canada |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Parkinsons DIsease: Models |
| Session: |
430. Neurodegenerative disorders: Parkinson's disease--neurotoxins Poster |
| Presentation Time: | Monday, November 12, 2001 2:00 PM-3:00 PM |
| Location: | Exhibit Hall WW-67 |
| Keywords: | neurotrophic factor, 6-hydroxydopamine, estrogen, neuroprotection |
Estrogen is neuroprotective within the nigrostriatal dopamine (DA) system; it preserves striatal DA after exposure to neurotoxins (Dluzen, 2000). Estrogen loss and replacement affect astrocytic FGF-2-IR in the VTA and DA cortical projection areas after ovariectomy (OVX) (Flores et al. 1999). In males astrocytic FGF-2-IR is increased in DA cell body regions after 6-OHDA lesions, a possible neuroprotective response to injury (Moroz & Stewart, SFN Abst 2000). We studied FGF-2-IR after 6-OHDA lesions in OVX adult females treated with either estradiol benzoate (EB) or OIL for 4 weeks before 6-OHDA lesions and killed after 3, 7, 14 d and 5 weeks. As in males, FGF-IR was increased in the ipsilateral SNc. The FGF-2 response in the VTA after lesion was smaller in females than in males and was significantly elevated only in OVX females treated with OIL. Lesions decreased TH-IR in ipsilateral SNc and VTA, but again to a lesser degree in females than was previously seen in males. We next examined whether 6-OHDA induced FGF-2-IR would vary as a function of perinatal exposure to testosterone (TP). At birth, males were either gonadectomized (GNDX) or not, and females were given TP or OIL. As adults all rats were GNDX, given EB or OIL for 4 weeks, then lesioned and killed 5 weeks later. In all rats lesions increased the number of FGF-2-IR cells and decreased TH-IR cells in the ipsilateral SNc and VTA. Although statistically not significant, animals exposed to testosterone at birth tended to have greater 6-OHDA induced FGF-2-IR in SNc and VTA. Thus, gonadal hormones seem to exert modest and localized alterations in the injury-induced astrocytic FGF-2-IR.
Supported by CIHR, NSERC (Canada), FCAR (Quebec).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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