Neuroscience 2005 Abstract
| Presentation Number: | 372.9 |
|---|---|
| Abstract Title: | Neurotrophin synergism is required for neuronal survival and axon regeneration after injury. |
| Authors: |
Logan, A.*1
; Ahmed, Z.1
; Gonzalez, A.1
; Baird, A.1
; Berry, M.1
1Medicine, Molecular Neuroscience Group, Univ. of Birmingham, Birmingham, United Kingdom |
| Primary Theme and Topics |
Development - Axonal and Dendritic Development -- Axon growth and guidance: MAG/Nogo/RGM |
| Secondary Theme and Topics | Development<br />- Transplantation and Regeneration<br />-- Regeneration: CNS |
| Session: |
372. Neurotrophins: Localization, Synthesis, Processing, and Release II Poster |
| Presentation Time: | Monday, November 14, 2005 8:00 AM-9:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # C6 |
| Keywords: | NEUROTROPHIC FACTOR, REGENERATION, INHIBITION, MYELIN |
Rescuing neurons from death and promoting axon regeneration through the delivery of individual neurotrophic factors (NTF) to the injured CNS has proved disappointing. Combined FGF2, NT-3, and BDNF trophically supports significantly more retinal ganglion cell (RGC) survival and neurite outgrowth in the presence of inhibitory CNS myelin than does the sum of the effects of each NTF given alone. We observed similar trophic synergism of combinatorial NTF treatment in vivo after optic nerve (ON) transection and intravitreal implantation of fibroblasts transfected to express fgf2/nt-3/bdnf, which promoted enhanced RGC survival and axon regeneration and abolished scarring in the ON rich in myelin- and non-myelin-derived inhibitory ligands. Triple but not single, NTF treatment activated regulated intramembraneous proteolysis (RIP) of p75NTR, leading to a reduction in intact p75NTR, and correlated with a 30% decrease in the production of Rho-GTP, a key downstream signalling molecule in the axon growth inhibitory cascade. We conclude that perisomatic delivery of combinations of NTF synergistically promotes CNS neuronal survival and disinhibits axon growth, leading to a failure in scarring.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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