Neuroscience 2003 Abstract
| Presentation Number: | 189.10 |
|---|---|
| Abstract Title: | Effects of estrogen on urethral function after pudendal nerve crush. |
| Authors: |
Ahmed, Y.*1,2
; Lin, D. L.1,2
; Ferguson, C. L.1,2
; Damaser, M. S.1,2
1Res. Service, Hines VA Hosp, Hines, IL 2IL, Res Serv (151) 5th Ave & Roosevelt Rd, 60141, |
| Primary Theme and Topics |
Autonomic, Neuroendocrine and Other Homeostatic Systems - Autonomic -- Gastrointestinal and urogenital regulation |
| Secondary Theme and Topics | Motor Systems<br />- Muscle and Motor Unit<br />-- Physiology |
| Session: |
189. Micturition & Bladder Control Poster |
| Presentation Time: | Sunday, November 9, 2003 9:00 AM-10:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # J49 |
| Keywords: | RAT, URETHRA, ESTRADIOL, TIMING |
Stress Urinary Incontinence (SUI) is correlated with pudendal nerve injury and resultant denervation of the external urethral sphincter (EUS) after vaginal delivery. Symptoms of SUI typically surface during menopause, suggesting hormonal participation in its etiology. Estrogen is also a potent neuroregenerative agent and might be useful to promote recovery from nerve injury. In the present study, we sought to pinpoint the time, relative to pudendal nerve injury, that estrogen (E2) administration would have its greatest effect. The pudendal nerve was crushed in 58 ovariectomized virgin rats and 22 rats were used as sham controls. E2 was administered subcutaneously 6 days prior to nerve crush (n=14), at the time of nerve crush (n=16), or 2 days after nerve crush (n=14). Sham implants were given at the time of nerve crush (n=14). Seven days after nerve crush, the rats were anesthetized for leak point pressure testing. Gentle pressure was applied to each rat's abdomen and was slowly increased until leakage of saline through the urethra, followed by rapid removal of the pressure. Mean values of peak leak point pressure (LPP) and external abdominal pressure (Pabd), were calculated for each group. LPP and Pabd were significantly decreased 7 days after nerve crush compared to sham controls. Although no significant differences in LPP or Pabd were shown between the nerve crush group with no E2 and each of the 3 nerve crush groups with E2, a clear trend was observed. E2 given at the time of nerve crush resulted in increased LPP and Pabd compared to the nerve crush rats with no E2. A similar result was obtained when E2 was given after nerve crush. E2 pretreatment did not increase either LPP or Pabd, implying a sensitization of the EUS and/or pudendal nerve to E2. We conclude that estrogen may promote recovery from pudendal nerve injury when given concurrent with nerve injury.
Supported by Veterans Administration
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
Copyright © 2003-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
