Neuroscience 2003 Abstract
| Presentation Number: | 189.2 |
|---|---|
| Abstract Title: | The urethral closing mechanism preventing stress urinary incontinence (sui) induced by the bladder­to­urethral reflexes. |
| Authors: |
Torimoto, K.*1
; Yoshimura, N.1,2
; Araki, I.3
; Chancellor, M. B.1
; de Groat, W. C.2
; Kamo, I.4
1Urology, Univ. Pittsburgh, Pittsburgh, PA 2Pharmacol., Univ. Pittsburgh, Pittsburgh, PA 3Japan, 3459 Fifth Ave, 15213, 4Urology, 3459 Fifth Ave, 15213, |
| Primary Theme and Topics |
Autonomic, Neuroendocrine and Other Homeostatic Systems - Autonomic -- Gastrointestinal and urogenital regulation |
| Session: |
189. Micturition & Bladder Control Poster |
| Presentation Time: | Sunday, November 9, 2003 9:00 AM-10:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # J49 |
| Keywords: | RAT, LEAK POINT PRESSURE |
The urethral continence mechanism during passive increments in intravesical pressure (Pves) was investigated by microtip transducer catheters in urethaneanesthetized female rats. Following acute spinal cord transection (Th89) that prevented reflex bladder contractions, when Pves was clamped at 20, 40 or 60cmH2O for 2 minutes, a restricted portion of the middle to proximal urethra (12.515 mm from the urethral orifice) showed contractile responses that were abolished by cutting the pelvic nerves (PN) bilaterally. In PNintact rats, bilateral transection of either pudendal nerves, nerves to iliococcygeous/pubococcygeous muscles or hypogastric nerves significantly reduced the urethral contractile response induced by passive Pves increases, and combined transection of these three sets of nerves totally abolished the urethral closing responses. Similar magnitude of urethral contractile responses during passive Pves elevation to 20 to 40 cmH2O was also observed in spinal intact rats when the response was measured before bursting activity of the urethra was induced. In PNtransected spinalized rats, leak point pressure (LPP) defined as the Pves inducing fluid leakage from the urethral orifice during passive elevation of Pves induced by either bladder pressure clamping in 2.5 cmH2O steps or direct compression of the bladder was significantly lowered by 3035% compared with shamoperated rats. These results indicate that: (1) passive elevation of Pves can elicit pelvic afferent nerveevoked contractile reflexes organized in the lumbosacral spinal cord in the restricted portion of urethra mediated by activation of sympathetic and somatic nerves, (2) these bladdertourethral reflexes induced by passive Pves elevation significantly contribute to the prevention of SUI.
Supported by NIH DK57267
<B>Conflict of Interest:</B> NIH DK57267
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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