Neuroscience 2000 Abstract
| Presentation Number: | 188.11 |
|---|---|
| Abstract Title: | Mild traumatic brain injury and the dose response fallacy. |
| Authors: |
LeFever, F. F.*
|
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 137. Trauma |
| Secondary Theme and Topics | I. Neural Basis of Behavior<br />- 116. Stress |
| Session: |
188. Trauma: mechanisms and methodology Poster |
| Presentation Time: | Sunday, November 5, 2000 3:00 PM-4:00 PM |
| Location: | Hall G-J |
| Keywords: | Cytokines, Heat Shock Proteins, Apoptosis, Autoimmunity |
Non-monotonic effects are known in pharmacology and in behavior (e.g. Yerkes-Dodson Law) but naive equating of structure and function makes it seem so self-evident that minimal neural loss after mild trauma precludes more than minimal and transient functional loss that many overlook reports of chronic neural and behavioral functional changes after trauma or ischemia with little or no cell loss (e.g. Lyeth et al. 1990, Heim et al. 1990, Dixon et al. 1995, Sanders et al. 2000). Effects of mild insults may differ from severe in type, not intensity (e.g. Bonfoco et al. 1995). Paradoxically, some may be greater to mild insults (e.g. Phillips & Betardo 1992). Beyond acute recovery, do they prevent or promote problems? LeFever cited detrimental neuroimmune reactions of cells stressed, not killed, and fluctuating, not fixed, cognitive deficits (INS 1995, SFN 1996, 1997, 1998, 1999). Protective heat shock proteins may violate dose response assumptions (Hickey et al. 1986), are widespread after brain trauma (e.g. Truettner et al. 1999), and may promote autoimmune reactions and neural dysfunction without overt damage (Sigal & Williams 1997), with profound behavioral effects (cf. Trifiletti & Packard 1999). Those at synapses (Bechtold & Brown 2000) might be especially potent mediators of stress-induced transient deficits (cf. Fukudo et al. 1997).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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