Neuroscience 2002 Abstract
| Presentation Number: | 181.16 |
|---|---|
| Abstract Title: | ERP Indices of Processing Speed and Working Memory Deficits in Systemic Lupus Erythematosus. |
| Authors: |
Shucard, J. L.*1,2
; McCabe, D. C.1,2
; Shucard, D. W.1,2
; Abara, J. P.1,2
; Savage, J. A.1,2
; Ambrus, Jr., J.3
1 Neurology, SUNY Buffalo School of Medicine, Buffalo, NY 2Psychology, SUNY Buffalo School of Medicine, Buffalo, NY 3Medicine, SUNY Buffalo School of Medicine, Buffalo, NY |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Executive function: Working memory |
| Session: |
181. Human cognition and behavior: working memory I Poster |
| Presentation Time: | Sunday, November 3, 2002 4:00 PM-5:00 PM |
| Location: | Hall A2-B3 P-18 |
| Keywords: | AUTOIMMUNITY, ATTENTION, COGNITION, FRONTAL LOBE |
Up to 70% of patients with Systemic Lupus Erythematosus (SLE) have deficits in cognitive functioning. These cognitive deficits have been most associated with information processing speed and working memory (WM). We hypothesized that the P3 component of the ERP, recorded during 2-back verbal and spatial WM tasks (V-WM; S-WM), would reflect processing speed and WM deficits in SLE. ERP and neuropsychological data were obtained for 16 SLE patients and 16 controls. P3 amplitudes and latencies were recorded to the first letter (prime), the middle letter (while information is held in WM) and the final letter (either a correct match with prime, GO; or not a match, NoGo) of the 2-back tasks. Results showed that for the S-WM task, controls had greater P3 amplitude than SLE patients at parietal sites for Go and NoGo, but not for the prime or the middle letter. At the frontal sites, SLE patients had greater P3 amplitude than controls for the prime and the middle letter, but not for Go and NoGo. P3 measures were also compared with performance on the Paced Auditory Serial Addition Test (PASAT), which places high demands on processing speed, attention, and WM. The SLE group was divided into high and low PASAT performance. P3 amplitude and latency differences were present between the two PASAT groups for both V-WM and S-WM tasks. These findings suggest:(a)that the P3 amplitude differences between SLE and controls are dependent on both the cognitive processes involved in the different elements of the WM task, and on the electrode scalp site (frontal vs parietal); and (b)that the ERP is sensitive to the processing speed and WM deficits present in SLE.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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