Neuroscience 2005 Abstract
| Presentation Number: | 115.17 |
|---|---|
| Abstract Title: | Translocation of mRNAs by FMRP between stress granules and polyribosomes after synaptic stimulation. |
| Authors: |
Kim, S.*1,2
; Weiler, I.1
; Greenough, W. T.1,2,3
1Beckman Inst., Univ. of Illinois, Urbana, IL 2Neuroscience Program, Univ. of Illinois, Urbana, IL 3Depts. of Psychology, Psychiatry and Cell and Structural Biology, Univ. of Illinois, Urbana, IL |
| Primary Theme and Topics |
Disorders of the Nervous System - Developmental Disorders -- Genetic |
| Session: |
115. Down's and Fragile X Syndromes Poster |
| Presentation Time: | Saturday, November 12, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # WW13 |
| Keywords: |
FMRP, lack of which causes Fragile X syndrome, is an RNA-binding protein which can regulate the translation of a subset of mRNAs (Miyashiro et al., Neuron, 2003; Weiler et al., PNAS, 2004). While expression of individual mRNAs may be either higher or lower in FMRP-KO mice, the mechanism of translational regulation by FMRP is still unknown. In response to various sorts of stress (heat, chemical or injury stress) and synaptic stimulation, FMRP-containing “stress granules” form and FMRP shuttles between stress granules and polyribosomes (Mazroui et al., Hum Mol Genet, 2002, Weiler et al., SfN 2003, Kim et al., SfN 2004). We now report that stress granules contain at least 3 mRNAs which are known to be bound by FMRP: fmr1, adenylate cyclase 3, and glucocorticoid receptor. We also found that stress granules include such ribosomal proteins as S6, L4, L7a, but not L3, L28, which suggests that they do not harbor complete ribosomes like RNA granules previously described by Aschrafi et al., PNAS, 2005. These observations suggest that FMRP may control translation of some mRNAs by translocating them between stress granules and polyribosomes after synaptic stimulation, and stress granules might serve as a repository of not only mRNAs but some ribosomal proteins which are necessary for rapid translational machinery setup.
Supported by NIMH, FRAXA Research Foundation, Illinois-Eastern Iowa District of Kiwanis International Spastic Paralysis Research Foundation and PO1 AG10154-12S1
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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