Neuroscience 2005 Abstract
| Presentation Number: | 891.21 |
|---|---|
| Abstract Title: | Orbitofrontal cortex dysfunction in compulsive cocaine seeking in the rhesus monkey. |
| Authors: |
Bradberry, C. W.*2
; Heitz, R. P.3
2Neuroscience, Univ. of Pittsburgh, Pittsburgh, PA 3GA, 3025 E. Carson, 15203, |
| Primary Theme and Topics |
Cognition and Behavior - Motivation and Emotion -- Decision making |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Executive function |
| Session: |
891. Motivation and Emotion: Decision Making Poster |
| Presentation Time: | Wednesday, November 16, 2005 8:00 AM-9:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # OO12 |
| Keywords: | cognition, addiction, self-administration, primate |
Substance abusers show impaired performance on cognitive tests of decision making that engage the orbitofrontal cortex (OFC). This study evaluated the impact of chronic cocaine self-administration on OFC function in rhesus monkeys, using a stimulus reversal task. Two control animals trained to respond for food, and two animals that had chronically self-administered both cocaine and cocaethylene in progressive ratio comparisons of reinforcing efficacy over a period of two years were tested. Mean cumulative intakes were: cocaine 285 mg/kg and cocaethylene 68 mg/kg. A touch screen monitor was used to present stimuli and record responses, using E-prime software. Animals were chair restrained and rewarded with water. They were acquainted with the apparatus by initially being rewarded for touching a stimulus on the screen. Upon proficiency at that task, the reversal task was begun. Bitmap images were presented to the left and right of the screen. Touching one resulted in a larger water reward (3X) than the other. The location of presentation was randomly varied from trial to trial. A criterion of 19/20 correct trials led to stimulus reversal. Making 19/20 correct responses with the new contingency accomplished a “reversal” at which point two new images were presented for the next block. There were no differences between the two groups at the familiarization task, however, performance on the reversal task was markedly worse in the chronic cocaine animals. Most striking was the failure to achieve a single reversal by one of the cocaine animals. This same animal had shown compulsive like cocaine seeking in the progressive ratio studies, as indicated by a failure to extinguish responding upon saline substitution. Even after one month of saline sessions, over 11,000 responses were being made in each session. A progression to compulsive cocaine seeking in humans and animals only occurs in a subset of individuals. These data implicate OFC dysfunction in that transition.
Supported by DA10331, VA Med Res Serv
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
Copyright © 2005-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
