Neuroscience 2005 Abstract
| Presentation Number: | 779.4 |
|---|---|
| Abstract Title: | Effects of dopamine receptor manipulations on stimulus--reward learning. |
| Authors: |
Galarce, E. M.*1
; Sutton, J. M.1
; Muralidharan, A. M.1
; Holland, P. C.1
; Crombag, H. S.1
1Dept. Psychological & Brain Sciences, Johns Hopkins Univ., Baltimore, MD |
| Primary Theme and Topics |
Cognition and Behavior - Motivation and Emotion -- Reward |
| Secondary Theme and Topics | Cognition and Behavior<br />- Motivation and Emotion<br />-- Learning |
| Session: |
779. Reward: Other Neurotransmitter Mechanisms Poster |
| Presentation Time: | Tuesday, November 15, 2005 4:00 PM-5:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # RR49 |
| Keywords: | Conditioned reinforcement, Pavlovian-to-instrumental transfer, dopamine antagonist, mice |
Knowing how reward-associated cues influence instrumental behaviors is important for understanding many aspects of motivated behavior, including pathological states of motivation such as addiction. A prime example of this is the Pavlovian-to-instrumental transfer phenomenon (or PIT). In this procedure, after animals learn to associate a Pavlovian cue with reward (CS+) and, on separate occasions, learn to instrumentally respond for this reward, presentation of the CS+ during instrumental performance typically potentiates responding. Although little is known about the neurobiology of PIT, studies have clearly implicated glutamatergic (AMPA) and dopaminergic mechanisms. For instance, pretreatment with D1/D2-like (α-flupenthixol or Pimozide) antagonists was reported to disrupt PIT in rats (Dickinson et al, 2000). Here we further explore the role of dopamine receptor activation in PIT by pretreating C57/b6 mice, 10 min prior to PIT testing, with different IP doses of D1 or D2 receptor antagonists. We report that: 1) Lower doses of the D1-like receptor antagonist SCH23390 (0.015-0.03 mg/kg), although producing a trend towards a selective effect on CS+ potentiated responding, did not significantly affect PIT whilst higher doses (0.06-0.12 mg/kg) produced a non-selective reduction in both CS+ and baseline response levels; 2) All doses of the D2-like receptor antagonist Raclopride (0.075-0.6 mg/kg) non-selectively attenuated instrumental responding; 3) Doses of SCH23390 and Raclopride that non-selectively reduced levels of instrumental responding also depressed locomotor activity. Based on these results we conclude that, at least within the dose range used here, D1 or D2 antagonists do not selectively modulate the enhancing effects of Pavlovian cues on instrumental behavior. Although different doses of D1 or D2 antagonists, or a combination of these, may produce more selective effects, our study supports the view that dopamine receptors mediate a wide array of locomotor, activational and motivational processes. Funded by NIH (RR017688).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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