Neuroscience 2003 Abstract
| Presentation Number: | 32.17 |
|---|---|
| Abstract Title: | Corpus callosum axon guidance: the role of ephrins and Eph receptors. |
| Authors: |
Mendes, S. W.*1
; Liebl, D. J.1
1Dept. Neurol., Univ. of Miami, Miami, FL |
| Primary Theme and Topics |
Development - Axonal and Dendritic Development -- Axon growth and guidance: other |
| Session: |
32. Axon Growth and Guidance: Extracellular Signals--Molecules I Poster |
| Presentation Time: | Saturday, November 8, 2003 1:00 PM-2:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # B5 |
| Keywords: | axon guidance, corpus callosum, ephrins, Eph receptors |
Ephrins and Eph receptors have been implicated in a number of developmental processes including axon growth and guidance. This group of guidance molecules has been characterized as mainly inhibitory in nature, regulating the migration of growth cones through repulsive mechanisms. One of the best identified guidance roles for these molecules is their ability to regulate axonal crossing of the central nervous system (CNS) midline. While a great deal of information is known of a variety of guidance cues that regulate midline guidance, less is known of how ephrins and their receptors integrate these signals to regulate this process. Our studies have examined the role of B-class ephrins and Eph receptors in regulating developmental midline guidance of corpus callosum (CC) axons. Our results indicate that ephrins and Eph receptors are expressed in the developing fiber tract and extracellular environment at embryonic day (ED) 15, 16, 17, and 18, thus present to play a role in the guidance of these axons. Our preliminary immunohistochemical results indicate that of the B-class ephrins, both ephrin-B1 and ephrin-B2 are expressed within the CC tract during these time points. Ephrin-B3 is expressed as early as ED15 both rostral and caudal to the CC. In addition, specific EphB and EphA receptors are expressed in the developing CC tract at the earliest stages of growth across the midline. Examination of ephrin and Eph receptor knockout mice has shown that several B-class members contribute to regulate CC midline guidance. These defects are most pronounced in double combination knockout mice we have examined, suggesting compensatory mechanisms exist for several of these family members. These data support the hypothesis that ephrins and Eph receptors are expressed at critical CC developmental time periods and play a role in the growth and guidance of CC axons in the developing mouse forebrain.
Supported by Miami Project to Cure Paralysis
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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