Neuroscience 2005 Abstract
| Presentation Number: | 670.12 |
|---|---|
| Abstract Title: | Effect of acute pudendal nerve injury on external urethral sphincter activity in the rat. |
| Authors: |
PENG, C. W.*1
; CHEN, J. J.1
; CHANG, H. Y.1,2
; DE GROAT, W. C.2
; Cheng, C. L.3
1Inst. of Biomedical Engineering, National Cheng Kung Univ., Tainan, Taiwan Republic of China 2PA, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, 3USA, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, |
| Primary Theme and Topics |
Disorders of the Nervous System - Neuromuscular Diseases -- Peripheral nerve injury and repair |
| Secondary Theme and Topics | Sensory and Motor Systems<br />- Kinematics and EMG<br />-- Reflexes |
| Session: |
670. Peripheral Nerve Injury, Repair, and Disorders of Muscle Poster |
| Presentation Time: | Tuesday, November 15, 2005 11:00 AM-12:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # SS53 |
| Keywords: | SUI, cystometrograms, electromyograms, voiding efficiency |
Although pudendal nerve (PN) injury in the rat is an accepted animal model for studying stress urinary incontinence (SUI), the effect of acute PN injury on EUS function has not been examined in detail. In this study we evaluated the changes in urinary bladder function, EUS activity and leak point pressure (LPP) after acute PN transection in female Sprague-Dawley rats. Control cystometrograms (CMGs) and EUS electromyograms (EUS-EMGs) were conducted on rats (300-380 g, n=14) under urethane anesthesia and then unilateral pudendal nerve transection (UPNT) or bilateral pudendal nerve transection (BPNT) was performed. CMGs, EUS-EMGs and (LPP) tests were performed before and after the nerve transections. All animals exhibited micturition reflexes during control CMGs; however after UPNT and BPNT, voiding abnormalities were detected including a 25%-33% increase in volume threshold for initiating voiding, a three fold increase in residual volume and 20%-80% decreases in contraction amplitude, contraction duration, voided volume and voiding efficiency. The EUS EMG of rats with UPNT consisted of shorter periods of bursting activity, higher bursting frequency, and a reduction in the ratio of silent to active periods during voiding. After BPNT the busting almost disappeared, but there was still a small (10% of control) residual tonic EMG activity during bladder filling. A significant decrease (40%-50%) in LPP occurred after UPNT and BPNT. These results indicate that pudendal nerve injury in rats affects voiding behavior by changing EUS activity and impairing voiding efficiency.
<B>Conflict of Interest:</B> Supported by: National Science Council (NSC-93-2213-E-075A-002) and ITRI, Taiwan.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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