Neuroscience 2004 Abstract
| Presentation Number: | 656.14 |
|---|---|
| Abstract Title: | Frequency- and time-domain evaluation for predicting motor patterns in neonate rat spinal cord. |
| Authors: |
Williams, K. K.*1,2
; Sundar, K.2
; Hochman, S.1
; DeWeerth, S. P.1,2
1Physiology, Emory Univ, Atlanta, GA 2GA, 313 Ferst Dr, 30332, |
| Primary Theme and Topics |
Motor Systems - Spinal Cord -- Physiology |
| Secondary Theme and Topics | Motor Systems<br />- Spinal Cord<br />-- Motoneurons |
| Session: |
656. Spinal Cord: Physiology and Anatomy Poster |
| Presentation Time: | Tuesday, October 26, 2004 9:00 AM-10:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # FF16 |
| Keywords: | control systems, rhythmic, spectral analysis, fourier |
Removed from descending & sensory inputs, the isolated spinal cord produces motoneuron output representing the population-encoded actions of spinal neurons. Bath application of pharmacological agents gives rise to various rhythmic motor patterns that differ in burst shape & frequency. These patterns include 5HT-induced locomotor-like activity, bicuculline & strychnine (bic/strych)-induced synchronous bursting, & other unique bursting patterns (Dougherty et al 2001 SFN Abst). We are using MATLAB technical computing software to conduct frequency- and time-domain analyses on ventral root recordings of the aforementioned induced motor patterns. Our goals are to quantitatively characterize & distinguish between various motor outputs, as well as to develop methods to automatically determine the presence & quality of bursting activity.
We have evaluated burst variability & power spectra to extract pertinent features from the various waveforms. Interestingly, we have found that medium-frequency (12-200Hz) spectra show transient shifts during development of both 5-HT/NMDA & bic/strych-induced bursting. These temporal changes in medium frequencies may represent the role of subthreshold events in coordinating final motor activity. High-frequency (100Hz+) components, while not distinct for locomotor and non-locomotor states of increased activity, showed increasingly uniform high-frequency spectral distribution for bursting patterns of higher regularity. In order to evaluate this possible metric for bursting quality, we have conducted initial comparisons of various bursting pattern high-frequency distributions with time-domain analysis of the waveforms’ burst shape & period variability. Future work to identify these & other fundamental differences in motor outputs will be used to create realtime feedback loops for automated detection & control of locomotion.
We have evaluated burst variability & power spectra to extract pertinent features from the various waveforms. Interestingly, we have found that medium-frequency (12-200Hz) spectra show transient shifts during development of both 5-HT/NMDA & bic/strych-induced bursting. These temporal changes in medium frequencies may represent the role of subthreshold events in coordinating final motor activity. High-frequency (100Hz+) components, while not distinct for locomotor and non-locomotor states of increased activity, showed increasingly uniform high-frequency spectral distribution for bursting patterns of higher regularity. In order to evaluate this possible metric for bursting quality, we have conducted initial comparisons of various bursting pattern high-frequency distributions with time-domain analysis of the waveforms’ burst shape & period variability. Future work to identify these & other fundamental differences in motor outputs will be used to create realtime feedback loops for automated detection & control of locomotion.
Supported by NINDS-NS40440; NSF IBN-0131612
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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