Neuroscience 2002 Abstract
| Presentation Number: | 714.10 |
|---|---|
| Abstract Title: | Event-related fMRI Study of Object Decision Priming in Healthy Young and Old Adults. |
| Authors: |
Stern, Y.*1
; Hilton, H. J.1
; Zarahn, E.1
; Flynn, J.1
; Cooper, L.1
; Perera, G.1
1Columbia University, New York, NY |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Other higher functions |
| Session: |
714. Human cognition and behavior: other II Slide |
| Presentation Time: | Wednesday, November 6, 2002 3:15 PM-3:30 PM |
| Location: | Room 204A |
| Keywords: | Priming, fMRI, Aging |
Elder subjects are capable of priming on an object decision task. However, in contrast to young adults who continue to prime 1 week later, elders can no longer prime after a 20 minute delay. We hypothesized that there would be processing differences during initial exposure to the material between the 2 groups. In an ERfMRI study, 12 young and 10 old subjects had 2 exposure sessions for possible (P) and impossible (I) objects. Subjects then indicated whether intermixed exposed and non-exposed objects were P or I. Consistent with previous studies, both groups tended to show priming on this decision for P, but not I objects.
For the fMRI data obtained during the second exposure sessions, differential activation for P vs I objects (P-I) was correlated (across subjects) with the difference between P and I priming. A statistically significant positive slope for this relationship was observed at the left and right cingulate, superior frontal gyrus, left medial frontal gyrus, middle temporal gyrus, angular gyrus and right insula in the young but only at left superior frontal gyrus in the old.
The slope of this relationship was more positive in the young than the old at the left middle temporal gyrus, middle frontal gyrus, medial frontal gyrus, superior frontal gyrus, superior temporal gyrus and right cingulate gyrus. No areas were noted where the slope was more positive in the old than the young subjects.
These findings suggest a difference between young and old in the brain mechanisms that relate differential processing of P and I objects to their relative priming. This functional reorganization in the older subjects may underlie their lower level of priming and the lack of persistence in priming.
For the fMRI data obtained during the second exposure sessions, differential activation for P vs I objects (P-I) was correlated (across subjects) with the difference between P and I priming. A statistically significant positive slope for this relationship was observed at the left and right cingulate, superior frontal gyrus, left medial frontal gyrus, middle temporal gyrus, angular gyrus and right insula in the young but only at left superior frontal gyrus in the old.
The slope of this relationship was more positive in the young than the old at the left middle temporal gyrus, middle frontal gyrus, medial frontal gyrus, superior frontal gyrus, superior temporal gyrus and right cingulate gyrus. No areas were noted where the slope was more positive in the old than the young subjects.
These findings suggest a difference between young and old in the brain mechanisms that relate differential processing of P and I objects to their relative priming. This functional reorganization in the older subjects may underlie their lower level of priming and the lack of persistence in priming.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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