Neuroscience 2002 Abstract
| Presentation Number: | 700.10 |
|---|---|
| Abstract Title: | SIGMA RECEPTOR LIGANDS OR HYPOTHERMIA INHIBIT SPREADING DEPRESSION EVOKED BY INJURING THE NEOCORTICAL SLICE. |
| Authors: |
Church, A. J.*1
; Andrew, R. D.1
1Dept Anat & Cell Biol, Queen's Univ, Kingston, Canada |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Trauma -- Brain |
| Session: |
700. Brain trauma: neuroprotection Poster |
| Presentation Time: | Wednesday, November 6, 2002 9:00 AM-10:00 AM |
| Location: | Hall A2-B3 Z-46 |
| Keywords: | NEUROPROTECTION, ISCHEMIA, TRAUMA, OPTICAL IMAGING |
Over a million North Americans suffer traumatic brain injury (TBI) each year. Of these, over 60,000 die and more than 80,000 suffer permanent disability. However no pharmacological agent can yet improve TBI. Primary TBI can cause recurring spreading depression (SD), a massive depolarization of neurons and glia lasting 1-2 min that increases metabolic stress and might promote secondary TBI. Using live rat neocortical slices we have shown that within minutes of injury SD exacerbates 1° TBI evoked by stabbing the slice (SFN abstr. 210.10, 2001). It may therefore be possible to improve TBI outcome by blocking SD immediately following a primary injury. Dextromethorphan (DM) is one of several σ1R agonists that block SD, an effect independent of NMDA receptor antagonism (SFN abstr. 332.6, 2001). Here we show that bath application of 30 μM DM or 100 μM BD-1063 (another σ1R ligand) can stop TBI-related SD (n=13/13, n=11/11 slices respectively). Coapplying the σ1R antagonist (+)-3-PPP (100 μM) reverses the DM effect (n=6/6 slices). Reducing the temperature from 35°C to 32°C also inhibits onset of TBI-related SD (n=10/10 slices) which could help explain why clinical hypothermia reduces 2° TBI. These data suggest that halting TBI-related SD with certain σ1R ligands or hypothermia may reduce 2° damage following injury.
Supported by The Heart and Stroke Foundation of Ontario, The Canadian Neurotrauma Research Program and The Canadian Institute for Health Research
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
Copyright © 2002-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
