Rhythmic network states have been theorized to facilitate communication between brain regions, but how these oscillations influence communication subspaces, i.e. the low-dimensional neural activity patterns that mediate inter-regional communication, and in turn how subspaces impact behavior remains unclear. Using a spatial memory task in rats (male Long-Evans rats), we simultaneously recorded ensembles from hippocampal CA1 and the prefrontal cortex (PFC) to address this question. We found that task behaviors best aligned with low-dimensional, shared subspaces between these regions, rather than local activity in either region. Critically, both network oscillations and speed modulated the structure and performance of this communication subspace. To understand the communication space, we visualized shared CA1-PFC communication geometry using manifold techniques and found ring-like structures. We hypothesize that these shared activity manifolds are utilized to mediate the task behavior. These findings suggest ...

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The causal relationship between gut microbiota (GM) and white matter injury and communication remains unclear. We aimed to scrutinize the plausible causal impact of GM on white matter hyperintensities (WMH), white matter microstructure, white matter connectivity and multiple neurological diseases via Mendelian randomization (MR) study. We identified 4 WMH-related bacterial taxa, including class Melainabacteria , order Gastranaerophilales , family Alcaligenaceae and genus Ruminiclostridium 6 . In addition, 3 bacterial taxa were discovered that have consistent effect on multiple aspects of white matter microstructure. Furthermore, we found 12 strong associations between genetic liability in GM and white matter connectivity. Among these bacterial taxa, family Clostridiaceae 1 demonstrated a protective effect against ischemic stroke (IS). Genus Barnesiella showed protective effect on IS and small vessel stroke (SVS) while posed a risk effect on neuromyelitis optica spectrum disorder (NMOSD), as well as on aqua...

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