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Mixing music with neuroscience to study social connectedness

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Week of March 4, 2019: Read the Latest Advocacy and Science News

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Project Brainstorm, a volunteer program run by graduate students of the Neuroscience Interdepartmental Ph.D. Program at UCLA, was founded as an outreach program bringing neuroscience education to Los Angeles area schools. Over the past five years, graduate students have been visiting classrooms in elementary, junior high and high schools to give interactive lessons covering such topics as functional anatomy, how the brain deals with drugs, and how neuronal communication works. The culminating activity of these visits has been when the students are broken up into small groups to spend time studying bird, rat and real human brains with the graduate students. In an effort to strengthen this relationship between Project Brainstorm and the Los Angeles community, the Brain Research Institute (BRI) at UCLA for the past two years has invited five schools to individually come to campus to learn about neuroscience during Brain Awareness Week. Each day began in an anatomy lab with discussions and demonstrations of br...

Motor skill learning enables organisms to interact effectively with their environment, relying on neural mechanisms that integrate sensory feedback with motor output. While sensory feedback, such as auditory cues linked to motor actions, enhances motor performance in humans, its mechanism of action is poorly understood. Developing a reliable animal model of augmented motor skill learning is crucial to begin dissects the biological systems that underpin this enhancement. We hypothesized that continuous auditory feedback during a motor task would promote complex motor skill acquisition in mice. We developed a closed-loop system using DeepLabCut for real-time markerless tracking of mouse forepaw movements with high processing speed and low latency. By encoding forepaw movements into auditory tones of different frequencies, mice received continuous auditory feedback during a reaching task requiring vertical displacement of the left forepaw to a target. Adult mice were trained over four days with either auditor...

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