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of 19679 results
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AbstractTraumatic spinal cord injury (SCI) results in persistent functional deficits due to the lack of axon regeneration within the mammalian CNS. After SCI, chondroitin sulfate proteoglycans (CSPGs) inhibit axon growth via putative interactions with the LAR-f...Oct 20, 2019
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AbstractPrecise subcellular clustering of neurotransmitter receptors and ion channels is essential for normal synaptic transmission and neuronal excitability. Perhaps the best-studied example of such clustering is at excitatory synapses, where the ‘scaffold’ pr...Oct 20, 2019
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AbstractThe endoplasmic reticulum (ER) has a dynamic interconnected network responsible for maintaining cellular homeostasis including local calcium ion concentration, lipid metabolism and protein synthesis. Multiple cellular malfunctions such as disturbance of...Nov 15, 2017
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AbstractPropriospinal neurons can relay functional information past incomplete spinal cord injuries (SCI) and are good candidates to target for restoring neural connectivity across anatomically complete SCI. Propriospinal neurons do not regrow spontaneously acr...Nov 14, 2017
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AbstractSpinal cord injury (SCI) leads to permanent disability in mammals because injured axons do not regenerate across the lesion to reconnect their previous targets. The failure of axon regeneration is due to both extrinsic inhibitory factors, e.g., the chon...Nov 13, 2017
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AbstractMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and a major cause of neurological disability in young adults. There is robust evidence showing that immune-mediated axon damage is the major cause for progression of...Nov 13, 2017
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AbstractRetinal ganglion cell (RGC) axon regeneration is not spontaneous, but can be induced by inflammation, genetic manipulation, or other stimuli. However, regrowth to central targets is limited in part due to the inhibitory extracellular environment of the ...Nov 12, 2017
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AbstractPeripheral nerve injury is a debilitating disease characterized by loss of sensation and/or motor function at the affected site. Although fibers in the peripheral nervous system spontaneously regenerates after injury, in many cases, full functional rest...Nov 11, 2017
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AbstractIn previous studies we have shown that transection of the distal cervical sympathetic trunk (CST) results in glial plasticity in the intermediolateral cell column (IML) of the rat and mouse spinal cord, a response that results from the release of retrog...Nov 11, 2017
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AbstractPreviously we reported that transection of distal axons in the cervical sympathetic trunk (CST) leads to robust retrograde neuronal and glial plasticity in the upper thoracic spinal cord. One week following injury the parent sympathetic preganglionic ne...Nov 11, 2017
