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Adolescent nicotine use is particularly concerning due to increased susceptibility to long-term effects and dependence during this critical developmental period. This study investigates the therapeutic effects of thiamine on nicotine withdrawal-induced anxiety, anhedonia, and depression in rats. Adolescent rats received nicotine (2 mg/kg, s.c.) for 21 d, followed by 21 d of withdrawal. Thiamine (25 or 50 mg/kg, i.p.) was administered during exposure and withdrawal. Behavioral assessments were used to evaluate anxiety- and depressive-like symptoms, and biochemical analyses measured oxidative stress markers, serotonin levels, MAO activity, BDNF, and GFAP as indicators of neuroinflammation in the prefrontal cortex. Nicotine withdrawal significantly elevated anxiety-, depression-, and anhedonia-like behaviors, increased oxidative stress, and upregulated MAO-A activity and GFAP expression, indicating neuroinflammatory effects. Notably, thiamine administration during both nicotine exposure and withdrawal effecti...

The Florida State University Neuroscience Program Outreach has become a staple within Leon County, increasing neuroscience awareness every year. During the 2018-19 academic year, graduate students visited high school classrooms and middle school classro...

SfN Past Presidents Eve Marder and Huda Akil were each awarded the National Medal of Science by President Joe Biden in a ceremony on October 24. The National Medal of Science the highest recognition the U.S. bestows on scientists and engineers.

SfN Past Presidents Eve Marder and Huda Akil were each awarded the National Medal of Science by President Joe Biden in a ceremony on October 24. The National Medal of Science the highest recognition the U.S. bestows on scientists and engineers.

We look forward to welcoming attendees to San Diego on November 12-16. Due to COVID-19, there are uncertainties regarding travel. Please consult the travel resources listed below in order to help plan your trip. Consistent with national and international public health guidance, SfN strongly recommends all of those planning to attend Neuroscience 2022 to be fully vaccinated if possible, subject to the advice of their personal physician. SfN expects all in-person attendees of Neuroscience 2022 to assess and implement for themselves all local, national, and international safety protocols to ensure the most productive and healthiest in-person meeting.

A new reality and an old call for justice reshapes the SfN community.

Mammalian brains encode information in the spiking activity of populations of neurons. To study population coding in behaving animals, spikes from ensembles of hundreds of neurons can be recorded with extracellular electrodes and assigned to their sourc...

How informed is the public about the developments offered by brain research? A survey was conducted using a 95-assertion multiple-choice questionnaire, responded by marking yes, no, or I don't know. The opinions of 35 senior neuroscientists and 2158 members of the public of Rio de Janeiro were heard on 12 subjective issues such as the mind-brain relationship, and 83 objective issues such as learning. For the latter, the response chosen by 70% or more of neuroscientists was considered to be correct and used to assign a score to each respondent. While neuroscientists obtained an average of 87.1±6.7% correct answers, the public scored only 48.4±13.9%. Scores improved the most with schooling, followed by popular science magazine reading, and newspaper reading. Well- and poorly-known themes were identified. Further, profiles of how neuroscientists and the public view the brain could be drawn. Like neuroscientists, the public considers that the brain is organized in functionally different areas which communicate...

The Biomedical Informatics Research Network (BIRN) aims to enable scientists to conduct clinical imaging studies across multiple sites to test new hypotheses on larger cohorts. Given that many research groups have valuable existing (legacy) data, one goal of the Morphometry BIRN Testbed has been to assess the feasibility of pooled analysis of legacy structural imaging data. The present study aims to determine whether such legacy data can be meaningfully reanalyzed as a larger combined data set by using rigorous data curation and image analysis methods; in this case, to test the hypothesis that hippocampal volume decreases with age. Legacy T1-weighted MR and demographic data related to normal aging and Alzheimer's disease have been shared through the BIRN by UCSD (TL Jernigan; L Thal; D Salmon), MGH/BWH (M Albert; D Blacker; R Killiany), and Washington Univ. (R Buckner; J Morris). This preliminary report describes our work with older normal control data: UCSD (n=53/28F), MGH/BWH (n=36/22F), and WashU (n=49/...