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3931 - 3940
of 6879 results
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AbstractGABAA receptors containing the α5 subunit (α5GABAARs) are predominantly expressed in the hippocampus of the mammalian brain. α5GABAARs have been implicated in learning and memory, as α5 null mutant mice (KO) show enhanced performance in hippocampal-dependent tasks (J Neurosci 22(13):5572). We recently showed that α5GABAARs generate a tonic but not synaptic current in murine CA1 pyramidal neurons (PNAS 101:3662). Further, low concentrations of the anesthetic, etomidate selectively enhance the tonic but not synaptic currents in hippocampal neurons (SFN Abstract 2003 #571.2). Our aim was to determine if α5GABAARs contribute to the amnestic effects of anesthetics. Here we report that etomidate (0.1 µM) potentiated a tonic current in wild-type (WT) (29.7 ± 13.9 pA, n=7) but not KO neurons (4.2 ± 2.2 pA, n=7, p<0.05). Etomidate (1 µM) impaired long-term potentiation (LTP; theta-burst protocol) in CA1 pyramidal neurons from WT (149.9 ± 9.3%, n=4 vs.109.8 ± 11.4%, n=4: control vs. etomidate) but not in KO mice (16...Nov 15, 2005