In Notable Careers: Reflections on Science, Leadership, and Community five neuroscientists from the United States, France, and Argentina look back on the careers they built around scientific discovery and personal connection.

A decline in cognitive abilities is associated with the aging process, affecting nearly 33% of US adults over the age of 70, and is a risk factor for the development of dementia and Alzheimer's disease. Several studies have reported age-related alterations in the transcriptome in the hippocampus, a major site of memory storage that is among the first regions impacted with age, dementia, and Alzheimer's disease. However, much remains unknown about why these transcriptional changes exist in the aged hippocampus and how this impacts memory late in life. Here, we show that monoubiquitination of histone H2B (H2Bubi), an epigenetic mechanism recently reported to be major regulator of the epigenome and transcriptome during memory formation in the young adult brain, decreases with age in the hippocampus of male rats. In vivo CRISPR-dCas9–mediated upregulation of Rnf20 , the only ubiquitin E3 ligase for H2B, in the hippocampus significantly improved memory retention in aged rats. Remarkably, RNA-seq analysis reveal...

A genetic variant associated with multiple psychiatric disorders drives changes in a brain network that may increase an individual’s risk of developing bipolar disorder and schizophrenia, finds a study published in JNeurosci.

Neuroscience 2024 Thank You for Attending #SfN24

Neuroscience 2024 Thank You for Attending #SfN24

Neuroscience 2024 Thank You for Attending #SfN24

Prospective students, advisers and neuroscience graduate program representatives have the opportunity to connect, learn, and engage.

The Society for Neuroscience Council has appointed a Search Committee to recommend a candidate to serve as Editor-in-Chief of eNeuro, SfN’s gold open-access journal. The Editor-in-Chief of eNeuro would be appointed for a 5-year term beginning January 1, 2025, after a period of transition with the current editor.

Dr. Volkow discusses the future of scientific solutions that could stem the national opioid public health crisis.

We acknowledge and support scientists who use animals in their work.