Thank you for attending #SfN23

Thank you for attending #SfN23

Thank you for attending #SfN23

Neuroscience 2021 Registration is Now Open.

The degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson’s disease. While some aspects of motor symptoms can be managed by dopamine replacement therapies, others respond poorly. Recent advancements in machine learning-based technologies offer opportunities to better understand the organizing principles of behavior modules at fine time scales and its dependence on dopaminergic modulation. In the present study, we applied the motion sequencing (MoSeq) platform to study the spontaneous locomotor activities of neurotoxin and genetic mouse models of Parkinsonism as the midbrain DA neurons progressively degenerate. We also evaluated the treatment efficacy of levodopa (L-DOPA) on behavioral modules at fine time scales. We revealed robust changes in the kinematics and usage of the behavioral modules that encode spontaneous locomotor activity. Further analysis demonstrates that fast behavioral modules with higher velocities w...

Recent research shows that the intention to act on an object alters its neural representation in ways as afforded by underlying sensorimotor processes. For example, the intention to grasp and pick up an object results in representations of the object's weight. But these representations become grasp-specific only immediately before object lift if weight information is relayed through object material. This feature triggers earlier representations regardless of intention probably because material–weight contingencies are overlearned. In contrast, recently learned weight cues should be recalled deliberately during grasp planning resulting in early grasp-specific representations. Here, we examined how action intentions affect the representation of newly acquired color–weight contingencies. We recorded electroencephalography while human participants grasped or reached for objects that varied in shape and density as indicated by their color. Multivariate analyses revealed a grasp-specific reactivation of color du...

Pain affects two thirds of patients following spinal cord injury (SCI). While its psychosocial impact is well-understood, we just begin to unravel the interaction between nociception and sensorimotor adaptation responsible for functional improvement. Re...

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Congress prevented a government shutdown by passing a continuing resolution (CR) that was later signed by the president »