The Arc gene is crucial in regulation and consolidation of long-term memory and its expression is tightly related to synaptic plasticity. The impact of Arc expression in memory may depend on its molecular mechanisms of mRNA metabolism that are now begin...

In the 50 years since the founding of the Society for Neuroscience, the field has advanced at a remarkable pace. As we celebrate 50 years of SfN, we will also continue to communicate the work of the volunteer leadership and the investments made to fulfill the core missions of SfN.

Read science policy and advocacy news from the week of March 30, 2018

Background: Stress is an inevitable part of human life, people begin to experience stress at early stages of life, even before birth. Prenatal stress has been linked to several diseases and disorders including many adverse neurobehavioral outcomes, whic...

Domestication is the process by which wild organisms are adapted for human use. Over time, isolated populations raised in captivity begin to diverge phenotypically from their wild counterparts in both morphology and behaviour. The lab rat, an important ...

Read science policy and advocacy news from the week of March 23, 2018

As policymakers stepped onto the escalator and looked out over the poster and exhibit floors at Neuroscience 2017, their jaws dropped.

For the next two years, SfN will hold individual membership prices at the 2016 rate »

Principal neurons (PNs) of the lateral superior olive (LSO) are a critical component of brain circuits that compare information between the two ears to extract sound source-location-related cues. LSO PNs are not a homogenous group but differ in their transmitter type, intrinsic membrane properties, and projection pattern to higher processing centers in the inferior colliculus. Glycinergic inhibitory LSO PNs have higher input resistance than glutamatergic excitatory LSO PNs (∼double). This suggests that the inhibitory cell type has a lower minimum input or signal intensity required to produce an output (activation threshold) which may impact how they integrate binaural inputs. However, cell type-specific differences in the strength of synaptic drive could offset or accentuate differences in intrinsic excitability and have not been assessed. To evaluate this possibility, we used a knock-in mouse model to examine spontaneous and electrically stimulated (evoked) synaptic events in LSO PN types using voltage-cl...