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Thank you for attending #SfN23

Thank you for attending #SfN23

Brain Awareness Week (BAW) is the global campaign to increase public understanding of neuroscience and advocate for science funding. Every March, BAW unites neuroscientists around the world in planning events and activities about brain research for people of all ages.

SfN supports women through resources, networking, awards, and education to raise awareness of implicit bias.

Recent work suggests that the brain represents probability distributions and performs Bayesian integration during sensorimotor learning. However, our understanding of the neural representation of this learning remains limited. To begin to address this, ...

Animals exhibit different patterns of social behavior throughout life. During early development members of many species perform different types of affiliative behavior, but after reaching sexual maturity begin performing territorial and reproductive beh...

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Thank you for attending #SfN23

The anterior cingulate cortex (ACC) plays a pivotal role in processing pain and emotion, communicating with both cortical and subcortical regions involved in these functions. The claustrum (CLA), a subcortical region with extensive connectivity to the ACC, also plays a critical role in pain perception and consciousness. Both ACC and CLA express Kappa (KOR), Mu (MOR), and Delta (DOR) opioid receptors, yet whether and how opioid receptors modulate this circuit are poorly understood. This study investigates the effects of opioid receptor activation on glutamatergic signaling in CLA→ACC circuitry using spatial transcriptomics, brain slice electrophysiology, optogenetics, and pharmacological approaches in mice of both sexes. Our results demonstrated that excitatory synaptic transmission generated by the CLA onto Layer 5 pyramidal (L5 PYR) cells in the ACC are reduced by KOR, MOR, and DOR agonists. However, only KOR agonists reduce monosynaptic transmission from the CLA onto L5 ACC PYR cells, highlighting the un...