Thank you for attending #SfN23

Thank you for attending #SfN23

Thank you for attending #SfN23

The endocannabinoid (eCB) signaling system is robustly expressed in the cerebellum from embryonic developmental stages to adulthood. It plays a key role in regulating cerebellar synaptic plasticity and excitability, suggesting that impaired eCB signaling could lead to deficits in cerebellar adjustments of ongoing behaviors and cerebellar learning. Indeed, human mutations in DAGLα are associated with neurodevelopmental disorders. In this study, we show that selective deletion of the eCB synthesizing enzyme diacylglycerol lipase alpha (Daglα) from mouse cerebellar Purkinje cells (PCs) alters motor and social behaviors, disrupts short-term synaptic plasticity in both excitatory and inhibitory synapses, and reduces PC activity during social exploration. Our results provide the first evidence for cerebellar-specific eCB regulation of social behaviors and implicate eCB regulation of synaptic plasticity and PC activity as the neural substrates contributing to these deficits. Significance statement Deletion of th...

SfN congratulates a trio of longtime scientific collaborators »

Review the satellite event policies and submit an event to be held at Neuroscience 2023.

Review the satellite event policies and submit an event to be held at Neuroscience 2023.

Aim: Regarding neuroreceptor PET studies a number of modelling approaches apply the cerebellum as reference area. Therefore, it is mandatory that the respective attenuation correction (AC) method for reconstructing the emission data is most appropriate ...

Understanding the ability to self-evaluate decisions is an active area of research. This research has primarily focused on the neural correlates of self-evaluation during visual tasks and whether neural correlates before or after the primary decision contribute to self-reported confidence. This focus has been useful, yet the reliance on subjective confidence reports may confound our understanding of key everyday features of metacognitive self-evaluation: that decisions must be rapidly evaluated without explicit feedback and unfold in a multisensory world. These considerations led us to hypothesize that an automatic domain-general metacognitive signal may be shared between sensory modalities, which we tested in the present study with multivariate decoding of electroencephalographic (EEG) data. Participants ( N  = 21, 12 female) first performed a visual task with no request for self-evaluations of performance, prior to an auditory task that included rating decision confidence on each trial. A multivariate cl...

The Society for Neuroscience (SfN) will present John Pollock, PhD; Nancy Michael, PhD; Taissa Lytchenko; and Brian Lim, with this year’s Science Education and Outreach Awards, comprising the Science Educator and the Next Generation Awards.