HISTORY OF NEUROSCIENCE LECTURE: Neuronal Migration and Brain Map Formation During Evolution, Development, and Disease - Pasko Rakic
Pasko Rakic, MD, PhD
Yale School of Medicine
Date & Time: Tuesday, November 14, 2017 2:30pm - 3:40pm
Neuronal position is fundamental to a neuron's identity, synaptic connections, and ultimately, function. For example, cortical neurons are not generated locally and acquire their areal, laminar, and columnar positions by migration from multiple distant sites of origin. Over the years, new experimental approaches have enabled identification of cellular mechanisms, genes, and molecular pathways that control neuronal production, fate, and migration to the proper position. These findings provide insight into brain evolution and development and the pathogenesis of its congenital disorders.