New Insights Into the Development and Treatment of Alzheimer’s Disease
Alzheimer’s disease is an age-related neurological disorder characterized by memory loss and dementia. As the number of Americans age 65 and older continues to grow, Alzheimer’s disease is affecting an increasing number of people. By 2025, the number of people with the disease in the United States is estimated to reach more than 7 million, presenting both social and economic challenges.
Despite its prevalence, the underlying causes for most cases of Alzheimer’s disease are currently unknown, and there is no preventative medicine or treatment.
Today’s new findings show that:
- Healthy elderly people with normal or superior memories can still exhibit signs of Alzheimer’s in their brains, suggesting they may possess protective mechanisms (Changiz Geula, abstract 284.1, see attached summary).
- Alzheimer’s disease may disrupt sleep-wake cycles in both humans and mouse models of the disease before other symptoms arise (Trongha Xuan Phan, abstract 205.06, see attached summary).
- A gene variant may contribute to the accumulation of brain plaques in the early stages of Alzheimer’s disease (Guojun Bu, abstract 225.27, see attached summary).
- A newly developed biomarker may predict response to a regenerative therapy for Alzheimer’s disease (Christine Solinsky, abstract 307.03, see attached summary).
The research was supported by national funding agencies such as the National Institutes of Health, as well as other public, private, and philanthropic organizations worldwide. Find out more about Alzheimer’s disease at BrainFacts.org.