Neuroscience 2005 Abstract
| Presentation Number: | 555.3 |
|---|---|
| Abstract Title: | White matter integrity in chronic schizophrenia patients ­ a diffusion tensor imaging study. |
| Authors: |
Rotarska-Jagiela, A.*1,2,3
; Oertel, V.1,2
; Formisano, E.
; Roebroeck, A.
; Rami, A.3
; De Martino, F.
; Schoenmeyer, R.1,2
; Haenschel, C.1,2
; Van de Ven, V.
; Maurer, K.1
; Linden, D. E. J.
1Psychiatry Dept., Goethe Univ., Frankfurt/Main, Germany 2Brain Imaging Center, Goethe Univ., Frankfurt/Main, Germany 3Dept. of Anatomy III, Goethe Univ., Frankfurt/Main, Germany |
| Primary Theme and Topics |
Disorders of the Nervous System - Cognitive, Emotional and Behavioral State Disorders -- Schizophrenia: Pathology |
| Session: |
555. Pathology of Schizophrenia I Poster |
| Presentation Time: | Monday, November 14, 2005 3:00 PM-4:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # TT1 |
| Keywords: | MYELIN, WHITE MATTER |
Growing evidence from post-mortem studies suggests involvement of white matter abnormalities in the pathology of schizophrenia. The development of a new magnetic resonance imaging (MRI) technique, Diffusion Tensor Imaging (DTI), allows examination of white matter track integrity in vivo.
We examined a group of chronic schizophrenia patients and age, gender, and education level matched controls. All participants underwent a MRI scan including a spin-echo EPI DTI sequence (TR/TE 5400/80ms, 40 slices, 1.8x1.8x2mm³ voxel size) on a 3T MRI Scanner (Siemens Allegra). Diffusion weighted images were acquired in 6 directions with b value = 1000s/mm². The original voxel size was interpolated to 1x1x1mm³. The data was aligned to high-resolution T1 weighted anatomical images and transformed into Talairach space. The resulting datasets were spatially smoothed with a 10mm Gaussian kernel.
White matter differences between the two groups were evaluated by comparing fractional anisotropy (FA) values in a whole-brain analysis. FA values were significantly lower in the patient group in several brain regions, including the splenium and truncus of the corpus callosum, cingulum, and parahippocampal gyrus, and significantly higher in left superior temporal gyrus, left frontal longitudinal superior fascicle and left lateral arcuate fascicle.
The current study provides further supporting evidence for white matter abnormalities in schizophrenia. The pattern of anisotropy changes suggests a wide-spread disturbance of anatomical connectivity in the brains of chronic schizophrenia patients, with both interhemispheric connections and connections between language and auditory areas prominently affected.
We examined a group of chronic schizophrenia patients and age, gender, and education level matched controls. All participants underwent a MRI scan including a spin-echo EPI DTI sequence (TR/TE 5400/80ms, 40 slices, 1.8x1.8x2mm³ voxel size) on a 3T MRI Scanner (Siemens Allegra). Diffusion weighted images were acquired in 6 directions with b value = 1000s/mm². The original voxel size was interpolated to 1x1x1mm³. The data was aligned to high-resolution T1 weighted anatomical images and transformed into Talairach space. The resulting datasets were spatially smoothed with a 10mm Gaussian kernel.
White matter differences between the two groups were evaluated by comparing fractional anisotropy (FA) values in a whole-brain analysis. FA values were significantly lower in the patient group in several brain regions, including the splenium and truncus of the corpus callosum, cingulum, and parahippocampal gyrus, and significantly higher in left superior temporal gyrus, left frontal longitudinal superior fascicle and left lateral arcuate fascicle.
The current study provides further supporting evidence for white matter abnormalities in schizophrenia. The pattern of anisotropy changes suggests a wide-spread disturbance of anatomical connectivity in the brains of chronic schizophrenia patients, with both interhemispheric connections and connections between language and auditory areas prominently affected.
Supported by Brain Imaging Center Frankfurt (BMBF - DLR 01GO0203)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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