Neuroscience 2000 Abstract
| Presentation Number: | 594.5 |
|---|---|
| Abstract Title: | Adaptation behavior of the rat olfactory bulb revealed by functional magnetic resonance imaging. |
| Authors: |
Xu, F.*1
; Kida, I.1
; Hyder, F.1
1MRC, Yale Univ Med Sch, New Haven, CT |
| Primary Theme and Topics |
F. Sensory Systems - 84. Chemical senses |
| Secondary Theme and Topics | I. Neural Basis of Behavior<br />- 106. Cognition: methods and models |
| Session: |
594. Chemical senses: imaging Slide |
| Presentation Time: | Wednesday, November 8, 2000 9:00 AM-9:15 AM |
| Location: | Room 291 |
| Keywords: | MAGNETIC RESONANCE IMAGING, OLFACTORY , ADAPTATION, ODOR |
The main olfactory bulb (MOB) is the first olfactory center where the olfactory information is coded and processed. In addition to integrating the activity from the olfactory epithelium, the responsive behavior is regulated further by intrinsic bulbar circuits and the extrinsic pathways from other brain regions. We are using functional magnetic resonance imaging (fMRI) to visualize the integrative effects of the regulation mechanisms on bulbar responsive behavior in rats. Using iso-amyl acetate as stimulant, the effects of odorant concentration, exposure duration, and intervals between stimulations on the responsive properties of the MOB were examined at 7-Tesla with spatial resolution of 220x220x250 μm and temporal resolution of 8s to 1.5 s/image. When rat was repeatedly exposed to odors, its MOB was activated to higher degree in the first stimulation, but was suppressed in following exposures. With longer stimulation, or higher concentration, the adaptation is more prominent. Activity dropped to ∼40% of the initial response in 2-minutes, than kept constant in continuous stimulation. With longer intervals between stimulations, the decrease of the activation is more gradual. The responsiveness can be partially recovered from adaptation by resting between experiments. However, the period for a complete recovery is about 30-minutes which is significantly longer than all known adaptation pathways, suggesting that other unknown mechanism(s) are involved in suppressing the bulbar response. Adaptation occurs across the MOB, but the spatial activity patterns, which are believed to code the olfactory information, are conserved.
Supported by NIH grants R01 DC03710, R01 DC/NS 03972, DC00210 and DBI-9730892.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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