Neuroscience 2005 Abstract
| Presentation Number: | 535.5 |
|---|---|
| Abstract Title: | Functional MRI of speech production. |
| Authors: |
Soros, P.*1
; Guttman Sokoloff, L.2
; Bose, A.3
; McIntosh, A. R.4
; Graham, S. J.1
; Stuss, D. T.4
1Imaging Research, Sunnybrook and Women's, Toronto, Canada 2ON, 2075 Bayview Ave, M6A 2E1, 3Canada, 2075 Bayview Ave, M6A 2E1, 4Speech-Language Pathology, 2075 Bayview Ave, M6A 2E1, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Language |
| Session: |
535. Language II Poster |
| Presentation Time: | Monday, November 14, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # KK33 |
| Keywords: | MOTOR CORTEX, CEREBELLUM, THALAMUS, BASAL GANGLIA |
Speech production requires the precise timing of around 100 muscles involved in articulation. The neural basis of the exact coordination of these movements is not entirely clear. Here we investigated brain activation associated with overt sub-lexical articulations using event-related fMRI with compressed image acquisition.
Nine young healthy volunteers (right-handed, fluent speakers of English; 5 men) were included. Subjects were asked to repeat acoustically presented speech sounds of different complexity and to perform non-verbal oral movements. The required responses were the vowel /a/, a consonant-vowel (CV) syllable (either /pa/, /ka/, or /ta/), a three-syllabic utterance (/pataka/), and oral movements (opening the mouth or protruding the lips). All instructions were delivered and all responses were made within the silent interval between the acquisition of the fMR images. Functional imaging was performed on a 3 Tesla MRI system with a standard head coil using a T2*-weighted spiral-in/out sequence.
The supplementary and cingulate motor areas, the bilateral mouth area of the primary motor cortex, the thalami and basal ganglia, the cerebellar hemispheres, and the superior temporal planes were activated in all conditions. Compared to the oral movement condition, the vowel and the CV syllable conditions showed increased activity in the bilateral auditory cortices. In the three-syllabic response, compared to oral movement, increased activity was found in the left cerebellar hemispheres and the bilateral auditory cortices.
This study demonstrates that speaking sub-lexical speech sounds involves cortical and subcortical motor centers similar to simple oral movements. More complex, polysyllabic utterances are associated with additional cerebellar activation, reflecting the sequencing of complex articulatory movements.
Nine young healthy volunteers (right-handed, fluent speakers of English; 5 men) were included. Subjects were asked to repeat acoustically presented speech sounds of different complexity and to perform non-verbal oral movements. The required responses were the vowel /a/, a consonant-vowel (CV) syllable (either /pa/, /ka/, or /ta/), a three-syllabic utterance (/pataka/), and oral movements (opening the mouth or protruding the lips). All instructions were delivered and all responses were made within the silent interval between the acquisition of the fMR images. Functional imaging was performed on a 3 Tesla MRI system with a standard head coil using a T2*-weighted spiral-in/out sequence.
The supplementary and cingulate motor areas, the bilateral mouth area of the primary motor cortex, the thalami and basal ganglia, the cerebellar hemispheres, and the superior temporal planes were activated in all conditions. Compared to the oral movement condition, the vowel and the CV syllable conditions showed increased activity in the bilateral auditory cortices. In the three-syllabic response, compared to oral movement, increased activity was found in the left cerebellar hemispheres and the bilateral auditory cortices.
This study demonstrates that speaking sub-lexical speech sounds involves cortical and subcortical motor centers similar to simple oral movements. More complex, polysyllabic utterances are associated with additional cerebellar activation, reflecting the sequencing of complex articulatory movements.
Supported by Centre for Stroke Recovery, Heart and Stroke Foundation of Ontario
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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