Neuroscience 2002 Abstract
| Presentation Number: | 568.7 |
|---|---|
| Abstract Title: | Neural responses accompanying periodic breathing in obstructive sleep apnea patients revealed by functional magnetic resonance imaging. |
| Authors: |
Macey, K. E.*1
; Henderson, L. A.1
; Macey, P. M.1
; Woo, M. A.3
; Frysinger, R. C.1
; Harper, R. K.1
; Yan-Go, F. L.2
; Alger, J. R.4
; Harper, R. M.1
1Dept Neurobiology, UCLA, Los Angeles, CA 2Dept Neurology, UCLA, Los Angeles, CA 3School of Nursing, UCLA, Los Angeles, CA 4Dept Radiological Sciences, UCLA, Los Angeles, CA |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Respiratory regulation |
| Secondary Theme and Topics | Autonomic, Limbic and Other Systems<br />- Biological Rhythms and Sleep |
| Session: |
568. Autonomic: respiratory regulation II Poster |
| Presentation Time: | Tuesday, November 5, 2002 3:00 PM-4:00 PM |
| Location: | Hall A2-B3 J-30 |
| Keywords: | LIMBIC, CEREBELLUM, AUTONOMIC, PONS |
Periodic breathing is associated with substantial alterations in autonomic outflow and extreme heart rate variation that accompany the cessation and resumption of respiratory efforts. The breathing pattern provides an opportunity to determine neural structures recruited to initiate and terminate breathing efforts, and to assess sites involved in mediating sympathetic and parasympathetic outflow. We examined signal changes in neural sites during periodic breathing in quiet sleep in two patients with obstructive sleep apnea. Twenty-five volumes of 20 image slices through the brain (Echo Planar technique) were collected using a GE 1.5T Signa scanner during a 2.5 min period of quiet sleep as determined by MR-compatible EEG techniques. The images were corrected for slice timing and motion, and were spatially and intensity normalized. Correlations between breathing rate and signal intensity were calculated, and significant voxels overlaid onto T1 anatomical images. During apneic periods, both patients showed significant signal changes in the dorsal pons extending into midbrain, paravermal and lateral cerebellar cortex, insula, anterior hypothalamus, and nucleus accumbens. The findings emphasize the traditional functions attributed to dorsal pontine and limbic structures in sympathetic outflow and respiratory patterning, and suggest that cerebellar regions play an additional role in patterning of periodic breathing.
Supported by NHLBI HL-60296
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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