Neuroscience 2004 Abstract
| Presentation Number: | 431.5 |
|---|---|
| Abstract Title: | Acupuncture activates the movement related brain areas: A pilot study of functional magnetic resonance imaging. |
| Authors: |
Lim, S.*1
; Choe, I.1
; Yoon, H.2
; Kim, C.3
; Park, H.1
1Meridian & acupoint, Col. of Oriental Med. in Kyunghee Univ., Seoul, Democratic People's Republic of Korea 2South Korea, #1 Hoegi-dong dongdaemun-gu, 130-701, 3fMRI Lab., #1 Hoegi-dong dongdaemun-gu, 130-701, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Brain Blood Flow, Metabolism, and Homeostasis -- Functional Imaging |
| Secondary Theme and Topics | Motor Systems<br />- Brainstem<br />-- Physiology |
| Session: |
431. Functional Imaging Poster |
| Presentation Time: | Monday, October 25, 2004 8:00 AM-9:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # II27 |
| Keywords: | acupuncture, fMRI, substantia nigra , parkinson |
Parkinson's disease is characterized by impaired initiation of movement, muscular rigidity and tremor clinically. In traditional Korean medicine, acupoints LR3 (Taechung) and GB34 (Yangneungcheon) have been used to treat such movement related disorders. Recently, we showed the neuroprotective and movement promoting effects of these acupoints with 6-OHDA induced Parkinson's disease rat model. In this study, we observed acupuncturing on (1) LR3 and (2) GB34 respectively, or on (3) both acupoints together activate movement-related brain areas with functional MRI (fMRI). Ten right-handed subjects participated in these fMRI experiments using a blocked paradigm on a 3T MRI scanner.
In the group of LR3, medial frontal gyrus (Left ;L), fusiform gyrus (L), cerebellum (L), pons (L) and thalamus (Right ;R) were activated. In the group of GB34, middle frontal gyrus (R), lingual gyrus (L), cerebellum (R), parahippocampal gyrus (L), insula (L), cingulate gyrus (R, BA24), posterior cingulate gyrus (L, BA29), claustrum (R), red nucleus (L) and thalamus (R) were activated. In the group of both LR3 and GB34 together, movement related areas such as globus pallidus (L), putamen (L), red nucleus (L, R) and substantia nigra (R) were activated, and inferior frontal gyrus (L), cingulate gyrus(L, R, BA24), precuneus of occipital lobe (R) and paracentral lobule(R) were activated as well. Interestingly, substantia nigra, the key area of Parkinson's disease, were activated just in the group of both acupoints.
These results might account for part of the mechanism that acupuncture could relieve Parkinson's disease like symptoms for thousands of years. In addition, appropriate combinations of acupoints are recommended to improve the efficacy of acupuncture treatment in clinic.
In the group of LR3, medial frontal gyrus (Left ;L), fusiform gyrus (L), cerebellum (L), pons (L) and thalamus (Right ;R) were activated. In the group of GB34, middle frontal gyrus (R), lingual gyrus (L), cerebellum (R), parahippocampal gyrus (L), insula (L), cingulate gyrus (R, BA24), posterior cingulate gyrus (L, BA29), claustrum (R), red nucleus (L) and thalamus (R) were activated. In the group of both LR3 and GB34 together, movement related areas such as globus pallidus (L), putamen (L), red nucleus (L, R) and substantia nigra (R) were activated, and inferior frontal gyrus (L), cingulate gyrus(L, R, BA24), precuneus of occipital lobe (R) and paracentral lobule(R) were activated as well. Interestingly, substantia nigra, the key area of Parkinson's disease, were activated just in the group of both acupoints.
These results might account for part of the mechanism that acupuncture could relieve Parkinson's disease like symptoms for thousands of years. In addition, appropriate combinations of acupoints are recommended to improve the efficacy of acupuncture treatment in clinic.
Supported by This work was supported by a research grant from the ministry of Health and Welfare of Korea. (02-PJ9-PG1-CO03-0005)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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