Neuroscience 2003 Abstract
| Presentation Number: | 414.9 |
|---|---|
| Abstract Title: | Comparision of multi-modal neuroimaging of fluid percussion injury: temporal and spatial alterations. |
| Authors: |
Obenaus, A.*1
; Snissarenko, E.1,2
; Gillard, E.2
; Lee, S.3
; Curras-Collazo, M.2
1Radiation Med., Loma Linda Univ., Loma Linda, CA 2CA, 11175 Campus St, CSP A1010, 92354, 3USA, 11175 Campus St, CSP A1010, 92354, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Trauma -- Brain |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Demyelinating Disorders |
| Session: |
414. Trauma: Brain II Poster |
| Presentation Time: | Monday, November 10, 2003 8:00 AM-9:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # LL3 |
| Keywords: | rat, MAGNETIC, hippocampus, cortex |
Neuroimaging is increasingly taking on a significant role in assessment of progression and outcome of neurotrauma, including magnetic resonance imaging (MRI). The fluid percussion model (FPI) was used for the induction of brain injury. FPI animals were imaged on a Bruker 4.7 T MRI (3, 24, 48 hr; 3, 4, 7 day) using: 1) T2-weighted-, 2) diffusion weighted, and 3) MR spectroscopy (MRS). A new gradient echo method, susceptibility weighted imaging (SWI), for visualization of extravascular blood was also assessed. Quantitative data analysis was obtained; T2 values (ms), apparent diffusion coefficients (ADC). MRS metabolites were quantified for: choline; creatine; N-acetyl aspartate; and lactate. SWI images were generated by minimum intensity projections.
FPI resulted in an increase in T2 values over the course of 7 days. The largest increases were found in the cortical regions, then hippocampus and thalamus. Increased ADC values in the cortical regions progressed over 7 days, and were accentuated on the side of injury. The hippocampus revealed slow progressive increase in ADC values. The T2/DWI results reflect increased levels of water and altered cellular composition. MRS had decreases in all metabolites on the side of the injury. Finally, SWI showed signal loss in selected regions within the brain but if these are correlated to extravascular blood awaits histological confirmation.
Thus in FPI, T2 is less sensitive than DWI for evolving pathology. MRS and SWI can predict more severe pathological outcomes at later times. Correlation of our imaging results with histology will assist in contributing to our understanding of mechanisms associated with post-injury inflammation and subsequent pathophysiology.
FPI resulted in an increase in T2 values over the course of 7 days. The largest increases were found in the cortical regions, then hippocampus and thalamus. Increased ADC values in the cortical regions progressed over 7 days, and were accentuated on the side of injury. The hippocampus revealed slow progressive increase in ADC values. The T2/DWI results reflect increased levels of water and altered cellular composition. MRS had decreases in all metabolites on the side of the injury. Finally, SWI showed signal loss in selected regions within the brain but if these are correlated to extravascular blood awaits histological confirmation.
Thus in FPI, T2 is less sensitive than DWI for evolving pathology. MRS and SWI can predict more severe pathological outcomes at later times. Correlation of our imaging results with histology will assist in contributing to our understanding of mechanisms associated with post-injury inflammation and subsequent pathophysiology.
Supported by UC Neurotrauma Program
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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