Neuroscience 2002 Abstract
| Presentation Number: | 478.5 |
|---|---|
| Abstract Title: | The PET activation study on the aged monkey with severely impaired learning ability. |
| Authors: |
Kondo, Y.*1
; Watanabe, K.1
; Ejima, N.1
; Imori, H.1
; Nagai, Y.1
; Sawada, T.1
1BF Resch Inst Inc, National Cardiovascular Ctr, Suita, Japan |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Aging<br />-- Physiology |
| Session: |
478. Animal cognition and behavior: learning and memory--physiology and imaging: metabolic and IEG mapping Poster |
| Presentation Time: | Tuesday, November 5, 2002 8:00 AM-9:00 AM |
| Location: | Hall A2-B3 Q-8 |
| Keywords: | aging, imaging, monkey, COGNITION |
To visualize the activity change between loose-shift and win-stay in the multiple discrimination reversal task, a positron emission tomography (PET) study with event-related and repeated 15O-H2O tracer injections in very short intervals was designed.
In this study, the tracer injections were controlled according to the subject's behavioral performances during PET scan, and the minimal injection interval was set 90 seconds.
Obtained PET images were re-sampled according to the tissue activity curve, and the re-sampled ones were classified to loose-shift, win-stay and resting based on the behavioral performances recorded simultaneously. The results of statistical parametric mapping (SPM) on the classified images were registered individually to the high-resolution structural magnetic resonance imaging (MRI) for anatomical determinations.
There is no or slight atrophy was observed from the structural MRI of the aged monkey brain.
The SPM99 revealed activation of the superior frontal gyrus (SFG), supramarginal gyrus (SMG), superior parietal lobule (SPL), annectant gyrus (AG) and occipital gyrus (OG) during loose-shift and SFG and AG during win-stay in the aged monkey brain. No activation of fasciolar gyrus (FG) and hippocampus (Hi) were observed in aged monkey.
Functionary, the aged monkey was able to reach to the reversal criteria, 15 continuous correct choices but required plenty of trials far from the chance level to win-shift.
These results may support relationship between the impaired learning ability of the aged monkey and the less activation of the FG and Hi because those of young ones were activated during win-stay.
In this study, the tracer injections were controlled according to the subject's behavioral performances during PET scan, and the minimal injection interval was set 90 seconds.
Obtained PET images were re-sampled according to the tissue activity curve, and the re-sampled ones were classified to loose-shift, win-stay and resting based on the behavioral performances recorded simultaneously. The results of statistical parametric mapping (SPM) on the classified images were registered individually to the high-resolution structural magnetic resonance imaging (MRI) for anatomical determinations.
There is no or slight atrophy was observed from the structural MRI of the aged monkey brain.
The SPM99 revealed activation of the superior frontal gyrus (SFG), supramarginal gyrus (SMG), superior parietal lobule (SPL), annectant gyrus (AG) and occipital gyrus (OG) during loose-shift and SFG and AG during win-stay in the aged monkey brain. No activation of fasciolar gyrus (FG) and hippocampus (Hi) were observed in aged monkey.
Functionary, the aged monkey was able to reach to the reversal criteria, 15 continuous correct choices but required plenty of trials far from the chance level to win-shift.
These results may support relationship between the impaired learning ability of the aged monkey and the less activation of the FG and Hi because those of young ones were activated during win-stay.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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