Neuroscience 2003 Abstract
| Presentation Number: | 386.16 |
|---|---|
| Abstract Title: | Distributed neural systems for saccadic eye movement in macaques and humans: a comparative fMRI study. |
| Authors: |
Koyama, M.*1
; Hasegawa, I.1
; Adachi, Y.
; Osada, T.
; Watanabe, T.1
; Miyashita, Y.1
1Dept. of Physiol, Sch. of Med., Univ. of Tokyo, Tokyo, Japan |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Attention |
| Secondary Theme and Topics | Motor Systems<br />- Oculomotor<br />-- Saccadic eye movements |
| Session: |
386. Visual Cortex: Active Vision Poster |
| Presentation Time: | Monday, November 10, 2003 11:00 AM-12:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # H19 |
| Keywords: | FUNCTIONAL MRI, FRONTAL, PARIETAL, NEUROIMAGING |
To directly compare functional brain architecture involved in the oculomotor control between macaque monkeys and humans, we conducted functional magnetic resonance imaging (fMRI) while subjects of both species performed equivalent oculomotor tasks. We applied a block design fMRI to identify brain areas activated during visually-guided saccade task compared to fixation baseline, and also used an event-related fMRI to characterize functional laterality of the activated areas. Three monkeys (Macaca fuscata) were scanned in a 4.7 T MRI scanner (Bruker, Germany). The eye positions were monitored with an infrared-sensitive CCD camera. In human experiments, twenty-two healthy subjects were scanned in a 1.5 T MRI scanner. Functional images were analyzed using SPM99. We found multiple bilateral activations related to saccadic eye movements in frontal and parietal cortex in both species. In macaques, activations in frontal cortex were found in the banks of the arcuate sulcus and the principal sulcus, and in the ventral premotor cortex. Parietal activations extended dorso-ventrally from the fundus to the lateral bank of the intraparietal sulcus and were also located in the posterior-most cortical surface in parietal cortex. In humans, frontal activations extended along the precentral sulcus and the superior frontal sulcus, while parietal activations were mainly in the superior parietal lobule. Comparison of regional activity related to leftward and rightward saccade revealed that dorsal/posterior activations in monkey/human parietal cortex showed clearer contraversive bias compared to frontal cortex. The comparison of the locus, extent, and laterality of the cortical eye fields between humans and macaques imposes constraints on the evolution of the cerebral cortex in primates.
Supported by a Grant-in-Aid for Specially Promoted Research (14002005) to Y.M. from MEXT.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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