Neuroscience 2005 Abstract
| Presentation Number: | 408.8 |
|---|---|
| Abstract Title: | Brain imaging predicts cognitive decline in aging: evidence of preclinical Alzheimer's disease. |
| Authors: |
Gitcho, A.*1
; Sun, F.1
; Kuczynski, B.1
; Mungas, D.2
; Haan, M.3
; Jagust, W.1
1Helen Wills Neuroscience Inst., UC Berkeley, Berkeley, CA 2CA, Helen Wills Neurosci Inst, 94720, 3USA, Helen Wills Neurosci Inst, 94720, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Cognitive aging |
| Session: |
408. Cognitive Aging II Poster |
| Presentation Time: | Monday, November 14, 2005 11:00 AM-12:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # DD5 |
| Keywords: | PET, MRI, TEMPORAL LOBE, PARIETAL CORTEX |
There is great interest in using biomarkers to predict who will develop Alzheimer’s disease (AD). Studies have used a variety of imaging modalities to investigate individuals with mild cognitive impairment and genetic risks as models of preclinical disease. In this study, we used positron emission tomography (PET) and magnetic resonance imaging (MRI) to detect metabolic and structural changes that predict cognitive decline in asymptomatic elderly people (> 60 yrs). Participants in this study were drawn from a subset of the Sacramento Area Latino Study of Aging (SALSA), N=61. These participants received MRI and PET and were neither demented nor cognitively impaired at baseline. The modified mini mental state examination (3MSE) and delayed recall (DelRec) examination were administered at approximate yearly intervals for an average follow up of 3.8 years. Rate of change in 3MSE/year and DelRec/year was correlated with baseline PET data and MR-measured volumes of entorhinal cortex and hippocampus. Baseline PET metabolism in left and right parietal lobes and left temporal lobes predicted rate of change on the 3MSE (p<0.001). Six individuals developed incident dementia or cognitive impairment (converters). Left hemisphere regions remained significant when converters were excluded. Left parietal cortex metabolism was associated with DelRec decline, but not when converters were excluded. Both hippocampal (p=0.03) and entorhinal cortical regions (p=0.01) predicted decline on DelRec over time, and entorhinal cortical volumes remained significant when converters were excluded (p=0.02). These brain volumes did not predict 3MSE decline. Our results show that global cognitive test decline is related to temporal and parietal metabolism, and memory test decline is related to medial temporal lobe brain volumes in normal older people. This detection of presymptomatic cognitive decline is consistent with the detection of presymptomatic AD pathology in healthy older individuals.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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