Neuroscience 2004 Abstract
| Presentation Number: | 346.2 |
|---|---|
| Abstract Title: | Functional magnetic resonance imaging of the primary sensorimotor cortex in schizophrenia: A meta-analysis. |
| Authors: |
Kindermann, S. S.*1,2
; Kwok, W.1
; Caligiuri, M.1,2
; Lohr, J.1,2
1Dep. Of Psychiatry, Univ. of California , San Diego, San Diego, CA 2CA, 3350 La Jolla Village Dr, 92161, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Psychiatric Disorders -- Schizophrenia--Functional defecits |
| Session: |
346. Schizophrenia: Functional Deficit I Poster |
| Presentation Time: | Sunday, October 24, 2004 2:00 PM-3:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # XX23 |
| Keywords: | MOTOR CORTEX, FMRI |
Several investigators have used motor challenges to study brain function in patients with schizophrenia. We were interested in learning more about the functional brain abnormalities that might underlie the motor difficulties so we performed a meta-analytic review of the functional magnetic imaging (fMRI) literature pertaining to motor tasks. We wanted to answer two questions. First, what is the magnitude of the difference in brain activity between patients and controls in tasks placing demands on primary sensorimotor cortex? Second, is there a reversal of normal primary sensorimotor cortical laterality in patients with schizophrenia? Six studies challenging the motor systems of predominantly right-handed subjects with finger tapping/sequencing tasks provided sufficient fMRI intensity information from which effect sizes (expressed as d-values and interpreted as standard deviation units) could be extracted. From these, we estimated a population effect size for the sensorimotor cortices of each hemisphere by the hand used. Patients with schizophrenia showed reduced activity in primary sensorimotor areas with larger decrements in the left than the right and the classification by hand was significant for each hemisphere. The results were inhomogeneous for the left hemisphere/right hand combination but the other three combinations were homogeneous, indicating that the values from the studies were estimating the same population value. The homogeneous values were: for the left hemisphere, left hand, d+ = -1.59; for the right hemisphere, left hand, d+ = -1.28; and for right hemisphere, right hand, d+ = +0.14. A negative sign indicates attenuated intensity in the patients compared to controls. Laterality thus appears compromised in primary sensorimotor cortex in patients with schizophrenia but the reversal hypothesis is not borne out.
Supported by VISN-22 MIRECC; NIMH
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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