Neuroscience 2000 Abstract
| Presentation Number: | 384.4 |
|---|---|
| Abstract Title: | Changes in early-and late-phase stroke lesions evaluated by T<SUB>2</SUB> maps, proton density maps, ADC maps and perfusion MRI. |
| Authors: |
Chen, Z.*1
; Abo, M.1
; Lai, L. J.1
; Andersson, B.1
; Bjelke, K.1
; Klason, T.1
; Reese, T.2
; Bjelke, B.1
1MR-Center, Karolinska Institutet, Stockholm, Sweden 2SmithKline Beecham, Biol., NMR, Herts, United Kingdom |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 136. Ischemia: functional outcome |
| Secondary Theme and Topics | H. Other Systems of the CNS<br />- 101. Brain metabolism and blood flow |
| Session: |
384. Ischemia: cerebral bloodflow II Poster |
| Presentation Time: | Monday, November 6, 2000 4:00 PM-5:00 PM |
| Location: | Hall G-J |
| Keywords: | IMAGING, HINDLIMB, MOTOR CURTEX, INCHEMIA |
The aim of this study was to evaluate the early- and late-phase brain lesion in experimental stroke models. Repeated in vivo qualitative and quantitative analysis was performed using advanced magnetic resonance imaging (MRI) techniques such as T2-, proton density (PD)- and apparent diffusion coefficient (ADC)- maps, and perfusion MRI. Under Isoflurane anaestesia male Sprague Dawley rats were subjected to a focal penumbra lesion (the early phase) or a focal pan-necrotic lesion (the late phase) in the sensori-motor cortex on the right side. The rats were than examined at the following time points, less than 3h, 6h, 12h and 24 h after the onset of the lesion. All MR measurements were made on a Biospec Avance 4.7Tesla spectrometer. Determination of T2 was done by the multislice multiecho experiment (MSME) and determination of the ADC was made by a conventional spin echo experiment. A bolus of a blood-pool contrast agent (Endorem, Guerbet, France, 11.2 mg Fe/ml, and 0.2 ml/rat) was rapidly injected via tail vein and a standard gradient echo experiment was performed for perfusion MRI analysis. A characteristic pattern over time, depending on the lesion, was found in the progression of the T2-, PD-, and ADC values. This analysis procedure are sensitive enough to detect the penumbra lesion. Thus, the method can be used in diagnosing and estimating the prognosis in brain lesions such as TIA, stroke or brain trauma. Acknowledgements: Trygg Hansas Forskningsstiftelse, David och Astrid Hageléns stiftelse, Stroke-Förbundets Stiftelser och Fonder.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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