Neuroscience 2005 Abstract
| Presentation Number: | 315.1 |
|---|---|
| Abstract Title: | Binding relations between temporally distinct items in working and long-term memory: evidence from functional magnetic resonance imaging. |
| Authors: |
Murray, L. J.*1,2
; Ranganath, C.1,2
1Center for Neuroscience, Univ. of California, Davis, Davis, CA 2Psychology, Univ. of California, Davis, Davis, CA |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Learning and long-term memory |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition, Behavior, and Anatomy<br />-- Working memory |
| Session: |
315. Long-Term Memory I Poster |
| Presentation Time: | Sunday, November 13, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # PP29 |
| Keywords: | HIPPOCAMPUS, PREFRONTAL CORTEX, FUNCTIONAL MRI, WORKING MEMORY |
The ability to form episodic memories requires one to bind relations between aspects of events that unfold over time. Several neuroimaging studies have investigated the encoding of specific items in isolation, however little is known about the neural mechanisms that support the formation of associations between temporally distinct items. Here, we used event-related functional magnetic resonance imaging (fMRI) to investigate the neural mechanisms of relational binding and item-specific processing in working memory (WM), and the impact of these operations on subsequent long-term memory (LTM) formation. During scanning, subjects made decisions about pairs of words separated by a delay of 9 seconds. On each trial, they were instructed to make a perceptual judgment about the first word (S1). When the second word (S2) appeared, they were either prompted to make a semantic decision specific to S2 (item-specific trials) or to make a decision that required comparison of S2 and S1 (relational trials). After scanning, subjects performed surprise recognition memory tests for each item and for the S1-S2 associations. Behavioral results show that memory for S2 was equivalent for both types of trials, whereas memory for S1 and S1-S2 associations was enhanced for relational, relative to item-specific, trials. Preliminary analyses of fMRI data revealed that activation in lateral prefrontal regions during processing of S2 was greater on relational trials than on item-specific trials. Activation in these areas was further enhanced during processing of S2 on trials for which the S1-S2 association was correctly remembered relative to trials on which the association was not remembered. These data suggest that the on-line working memory operations implemented by lateral prefrontal regions additionally facilitate the binding of temporally distinct items into lasting associative memories.
Supported by NIMH-RO1MH68721
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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